Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person DLL4 positively regulates expression of FLT1 (VEGFR1)

Class:Id	BlackBoxEvent:9979703
_displayName	DLL4 positively regulates expression of FLT1 (VEGFR1)
_timestamp	2026-03-18 16:42:13
authored	[InstanceEdit:9979677] May, Bruce, 2026-01-20
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9979669] May, Bruce, 2026-01-20
edited	[InstanceEdit:9979677] May, Bruce, 2026-01-20
input	[EntityWithAccessionedSequence:9979680] FLT1 gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9985318] D'Eustachio, Peter, 2026-03-18
isChimeric	FALSE
literatureReference	[LiteratureReference:9979458] Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells
modified	[InstanceEdit:9981887] May, Bruce, 2026-02-11 [InstanceEdit:9985321] May, Bruce, 2026-03-18
name	DLL4 positively regulates expression of FLT1 (VEGFR1)
output	[EntityWithAccessionedSequence:3004464] VEGFR1 [plasma membrane] [Homo sapiens]
participantCellType	[PhysicalEntityCellType:9979136] DLL4 [plasma membrane] in endothelial tip cell [PhysicalEntityCellType:9981842] FLT1 gene [nucleoplasm] in endothelial stalk cell [PhysicalEntityCellType:9981835] VEGFR1 [plasma membrane] in endothelial stalk cell
precedingEvent	[BlackBoxEvent:9917438] Expression of DLL4 is positively regulated by VEGFA, MEF2A,C,D, and ERG in endothelial tip cell [Homo sapiens] [Reaction:9917477] MEF2A,C,D:HDAC4,7,9:DLL4 gene releases HDAC4,7,9 and binds EP300 and ERG [Homo sapiens] [Reaction:5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9979689] Positive gene expression regulation by 'DLL4 [plasma membrane]'
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9979706] R-HSA-9979703.1
summation	[Summation:9979694] DLL4 causes increased expression of the low activity VEGF re...
(hasEvent)	[Pathway:9981845] NOTCH signaling regulates gene expression in endothelial stalk cells [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by DLL4 positively regulates expression of FLT1 (VEGFR1) (9979703)