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Details on Person VEGFA increases expression of CXCR4 in endothelial cells cul...
| Class:Id | Summation:9979690 |
|---|---|
| _displayName | VEGFA increases expression of CXCR4 in endothelial cells cul... |
| _timestamp | 2026-02-07 16:54:57 |
| created | [InstanceEdit:9979669] May, Bruce, 2026-01-20 |
| literatureReference | [LiteratureReference:9979699] Dll4 and Notch signalling couples sprouting angiogenesis and artery formation [LiteratureReference:9981215] Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching |
| modified | [InstanceEdit:9980985] May, Bruce, 2026-02-04 [InstanceEdit:9981222] May, Bruce, 2026-02-06 [InstanceEdit:9981355] May, Bruce, 2026-02-07 |
| text | VEGFA increases expression of CXCR4 in endothelial cells cultured ex vivo (Salcedo et al. 1999, 2003). CXCR4 that is expressed on an endothelial cell interacts with CXCL12 secreted by surrounding cells to directionally guide formation of new blood vessels (Pitulescu et al. 2017). In mice, enriched expression of Cxcr4 in tip cells is detected in laser-dissected retinas (Strasser et al. 2010) |
| (summation) | [BlackBoxEvent:9979674] VEGFA positively regulates expression of CXCR4 [Homo sapiens] |
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No pathways have been reviewed or authored by VEGFA increases expression of CXCR4 in endothelial cells cul... (9979690)
