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Details on Person RPS6KA2 phosphorylates LANA1

Class:IdReaction:9979226
_displayNameRPS6KA2 phosphorylates LANA1
_doReleaseFALSE
_timestamp2026-03-26 18:30:55
authored[InstanceEdit:9979119] Stephan, Ralf, 2026-01-15
catalystActivity[CatalystActivity:9979214] protein serine/threonine kinase activity of p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9979224] Stephan, Ralf, 2026-01-16
crossReference[DatabaseIdentifier:9857128] RHEA:17990
disease[Disease:3134794] viral infectious disease
goBiologicalProcess[GO_BiologicalProcess:3601] protein phosphorylation
input[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[Complex:9978548] LANA1 dimer [nucleoplasm] [Human herpesvirus 8]
internalReviewed[InstanceEdit:9985769] Orlic-Milacic, Marija, 2026-03-26
isChimericFALSE
literatureReference[LiteratureReference:9979219] Phosphorylation of the chromatin binding domain of KSHV LANA
modified[InstanceEdit:9983303] Stephan, Ralf, 2026-02-21
[InstanceEdit:9985748] Stephan, Ralf, 2026-03-25
[InstanceEdit:9985768] Stephan, Ralf, 2026-03-26
nameRPS6KA2 phosphorylates LANA1
output[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:9668967] H+ [nucleoplasm]
[SimpleEntity:9668967] H+ [nucleoplasm]
[SimpleEntity:9668967] H+ [nucleoplasm]
[SimpleEntity:9668967] H+ [nucleoplasm]
[Complex:9979213] p-S10,T14-LANA1 dimer [nucleoplasm] [Human herpesvirus 8]
precedingEvent
relatedSpecies[Species:2671781] Human herpesvirus 8
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9979228] R-HSA-9979226.1
summation[Summation:9979212] Host Ribosomal protein S6 kinase alpha-2 (RPS6KA2) phosphory...
(hasEvent)[Pathway:9976043] Maturation of Latency-Associated HHV8 Proteins [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9978628] PRMT1 methylates Arg-20 in LANA1 dimer [Homo sapiens]
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No pathways have been reviewed or authored by RPS6KA2 phosphorylates LANA1 (9979226)