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Details on Person Secreted NSP4 inhibits LCT

Class:Id	BlackBoxEvent:9979165
_displayName	Secreted NSP4 inhibits LCT
_doRelease	FALSE
_timestamp	2026-01-21 15:44:48
authored	[InstanceEdit:9979788] Orlic-Milacic, Marija, 2026-01-21
catalystActivity	[CatalystActivity:188991] lactase activity of LCT dimer [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9979163] Orlic-Milacic, Marija, 2026-01-15
disease	[Disease:3134794] viral infectious disease
input	[SimpleEntity:109276] H2O [extracellular region] [SimpleEntity:188973] Lac [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:9979171] An NSP4-dependant mechanism by which rotavirus impairs lactase enzymatic activity in brush border of human enterocyte-like Caco-2 cells
modified	[InstanceEdit:9979208] Orlic-Milacic, Marija, 2026-01-15 [InstanceEdit:9979789] Orlic-Milacic, Marija, 2026-01-21
name	Secreted NSP4 inhibits LCT
output	[SimpleEntity:188995] Gal [extracellular region] [SimpleEntity:70115] Glc [extracellular region]
precedingEvent	[BlackBoxEvent:9821733] NSP4 is secreted [Homo sapiens] [BlackBoxEvent:9821766] NSP4 localizes to caveolae [Homo sapiens]
regulatedBy	[NegativeRegulation:9979166] Negative regulation by 'NSP4 tetramer [extracellular region]'
relatedSpecies	[Species:9615053] Rotavirus A
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9979167] R-HSA-9979165.1
summation	[Summation:9979187] Rotavirus A (RV-A) nonstructural protein NSP4, secreted from...
(hasEvent)	[Pathway:9974192] Rotavirus A (RV-A) host interactions [Homo sapiens]
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No pathways have been reviewed or authored by Secreted NSP4 inhibits LCT (9979165)