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Details on Person vPK phosphorylates ORF59 dimer

Class:Id	Reaction:9979033
_displayName	vPK phosphorylates ORF59 dimer
_doRelease	FALSE
_timestamp	2026-03-26 18:32:10
authored	[InstanceEdit:9979119] Stephan, Ralf, 2026-01-15
catalystActivity	[CatalystActivity:9978806] protein serine/threonine kinase activity of p-S-vPK [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9979035] Stephan, Ralf, 2026-01-14
crossReference	[DatabaseIdentifier:9857128] RHEA:17990
disease	[Disease:3134794] viral infectious disease
goBiologicalProcess	[GO_BiologicalProcess:3601] protein phosphorylation
input	[SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [Complex:9979024] ORF59 dimer [nucleoplasm] [Human herpesvirus 8]
internalReviewed	[InstanceEdit:9985769] Orlic-Milacic, Marija, 2026-03-26
isChimeric	FALSE
literatureReference	[LiteratureReference:9979037] Phosphorylation of Kaposi's sarcoma-associated herpesvirus processivity factor ORF59 by a viral kinase modulates its ability to associate with RTA and oriLyt
modified	[InstanceEdit:9983303] Stephan, Ralf, 2026-02-21 [InstanceEdit:9983392] Stephan, Ralf, 2026-02-23 [InstanceEdit:9985311] Stephan, Ralf, 2026-03-18 [InstanceEdit:9985768] Stephan, Ralf, 2026-03-26
name	vPK phosphorylates ORF59 dimer
output	[SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:9668967] H+ [nucleoplasm] [SimpleEntity:9668967] H+ [nucleoplasm] [SimpleEntity:9668967] H+ [nucleoplasm] [SimpleEntity:9668967] H+ [nucleoplasm] [SimpleEntity:9668967] H+ [nucleoplasm] [SimpleEntity:9668967] H+ [nucleoplasm] [SimpleEntity:9668967] H+ [nucleoplasm] [SimpleEntity:9668967] H+ [nucleoplasm] [Complex:9979030] p-ORF59 dimer [nucleoplasm] [Human herpesvirus 8]
precedingEvent	[BlackBoxEvent:9979021] ORF59 dimer moves to nucleus [Homo sapiens] [Reaction:9978985] ORF59 forms dimer [Homo sapiens] [BlackBoxEvent:9976008] vPK translocates to the nucleus [Homo sapiens] [Reaction:9975997] vPK autophosphorylates [Homo sapiens]
relatedSpecies	[Species:2671781] Human herpesvirus 8
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9979039] R-HSA-9979033.1
summation	[Summation:9979038] HHV8 Viral protein kinase (vPK, ORF36) phosphorylates HHV8 D...
(hasEvent)	[Pathway:9976071] Maturation/Activation of Delayed Early Lytic HHV8 Proteins [Homo sapiens]
(precedingEvent)	[Reaction:9979049] p-ORF59 dimer binds ORF57 dimer [Homo sapiens] [Reaction:9979117] p-ORF59 dimer binds to PAN RNA [Homo sapiens]
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No pathways have been reviewed or authored by vPK phosphorylates ORF59 dimer (9979033)