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Details on Person vPK phosphorylates K8

Class:IdReaction:9978809
_displayNamevPK phosphorylates K8
_doReleaseFALSE
_timestamp2026-03-26 18:31:58
authored[InstanceEdit:9978803] Stephan, Ralf, 2026-01-08
catalystActivity[CatalystActivity:9978806] protein serine/threonine kinase activity of p-S-vPK [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9978807] Stephan, Ralf, 2026-01-08
crossReference[DatabaseIdentifier:9857128] RHEA:17990
disease[Disease:3134794] viral infectious disease
goBiologicalProcess[GO_BiologicalProcess:3601] protein phosphorylation
input[Complex:9978204] K8 dimer [nucleoplasm] [Human herpesvirus 8]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
internalReviewed[InstanceEdit:9985769] Orlic-Milacic, Marija, 2026-03-26
isChimericFALSE
literatureReference[LiteratureReference:9978306] Cell cycle regulation by Kaposi's sarcoma-associated herpesvirus K-bZIP: direct interaction with cyclin-CDK2 and induction of G1 growth arrest
[LiteratureReference:9978297] Kaposi's sarcoma-associated herpesvirus-encoded protein kinase and its interaction with K-bZIP
[LiteratureReference:9978403] K-bZIP of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV-8) binds KSHV/HHV-8 Rta and represses Rta-mediated transactivation
modified[InstanceEdit:9979035] Stephan, Ralf, 2026-01-14
[InstanceEdit:9983303] Stephan, Ralf, 2026-02-21
[InstanceEdit:9985311] Stephan, Ralf, 2026-03-18
[InstanceEdit:9985768] Stephan, Ralf, 2026-03-26
namevPK phosphorylates K8
output[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:9668967] H+ [nucleoplasm]
[SimpleEntity:9668967] H+ [nucleoplasm]
[Complex:9978805] p-T111-K8 dimer [nucleoplasm] [Human herpesvirus 8]
precedingEvent
relatedSpecies[Species:2671781] Human herpesvirus 8
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9978813] R-HSA-9978809.1
summation[Summation:9978810] As the lytic cycle progresses and vPK levels rise, vPK phosp...
(hasEvent)[Pathway:9976071] Maturation/Activation of Delayed Early Lytic HHV8 Proteins [Homo sapiens]
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