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Details on Person LANA1 dimer moves to nucleus

Class:IdBlackBoxEvent:9978553
_displayNameLANA1 dimer moves to nucleus
_doReleaseFALSE
_timestamp2026-03-26 18:26:20
authored[InstanceEdit:9978540] Stephan, Ralf, 2026-01-02
compartment[Compartment:13231] nuclear envelope
created[InstanceEdit:9978562] Stephan, Ralf, 2026-01-02
disease[Disease:3134794] viral infectious disease
goBiologicalProcess[GO_BiologicalProcess:781] intracellular transport of viral protein in host cell
input[Complex:9978525] LANA1 dimer [cytosol] [Human herpesvirus 8]
internalReviewed[InstanceEdit:9985769] Orlic-Milacic, Marija, 2026-03-26
isChimericFALSE
literatureReference[LiteratureReference:9978538] Carboxy terminus of human herpesvirus 8 latency-associated nuclear antigen mediates dimerization, transcriptional repression, and targeting to nuclear bodies
[LiteratureReference:9978546] Human herpesvirus-8-encoded LNA-1 accumulates in heterochromatin- associated nuclear bodies
[LiteratureReference:9978565] Close but distinct regions of human herpesvirus 8 latency-associated nuclear antigen 1 are responsible for nuclear targeting and binding to human mitotic chromosomes
[LiteratureReference:9978549] Kaposi's sarcoma herpesvirus C-terminal LANA concentrates at pericentromeric and peri-telomeric regions of a subset of mitotic chromosomes
[LiteratureReference:9978547] Conservation of complex nuclear localization signals utilizing classical and non-classical nuclear import pathways in LANA homologs of KSHV and RFHV
[LiteratureReference:9978564] Brd/BET Proteins Influence the Genome-Wide Localization of the Kaposi's Sarcoma-Associated Herpesvirus and Murine Gammaherpesvirus Major Latency Proteins
modified[InstanceEdit:9983303] Stephan, Ralf, 2026-02-21
[InstanceEdit:9985748] Stephan, Ralf, 2026-03-25
[InstanceEdit:9985768] Stephan, Ralf, 2026-03-26
nameLANA1 dimer moves to nucleus
output[Complex:9978548] LANA1 dimer [nucleoplasm] [Human herpesvirus 8]
precedingEvent
relatedSpecies[Species:2671781] Human herpesvirus 8
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9978569] R-HSA-9978553.1
summation[Summation:9978550] HHV8 Protein LANA1 is found exclusively in the host cell's n...
(hasEvent)[Pathway:9976043] Maturation of Latency-Associated HHV8 Proteins [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9978628] PRMT1 methylates Arg-20 in LANA1 dimer [Homo sapiens]
[Reaction:9979226] RPS6KA2 phosphorylates LANA1 [Homo sapiens]
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