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Details on Person CDKs phosphorylate K8

Class:IdReaction:9978294
_displayNameCDKs phosphorylate K8
_doReleaseFALSE
_timestamp2026-03-26 18:44:00
authored[InstanceEdit:9978211] Stephan, Ralf, 2025-12-29
catalystActivity[CatalystActivity:9978304] protein serine/threonine kinase activity of CDK1:CCNB,CDK2:CCNA,E [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9978309] Stephan, Ralf, 2025-12-30
crossReference[DatabaseIdentifier:9857128] RHEA:17990
disease[Disease:3134794] viral infectious disease
goBiologicalProcess[GO_BiologicalProcess:3601] protein phosphorylation
input[Complex:9978204] K8 dimer [nucleoplasm] [Human herpesvirus 8]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
internalReviewed[InstanceEdit:9985769] Orlic-Milacic, Marija, 2026-03-26
isChimericFALSE
literatureReference[LiteratureReference:9978296] Kaposi's sarcoma-associated herpesvirus K-bZIP protein is phosphorylated by cyclin-dependent kinases
[LiteratureReference:9978306] Cell cycle regulation by Kaposi's sarcoma-associated herpesvirus K-bZIP: direct interaction with cyclin-CDK2 and induction of G1 growth arrest
[LiteratureReference:9978297] Kaposi's sarcoma-associated herpesvirus-encoded protein kinase and its interaction with K-bZIP
modified[InstanceEdit:9983303] Stephan, Ralf, 2026-02-21
[InstanceEdit:9985311] Stephan, Ralf, 2026-03-18
[InstanceEdit:9985776] Stephan, Ralf, 2026-03-26
nameCDKs phosphorylate K8
output[Complex:9978305] p-T111,S167-K8 dimer [nucleoplasm] [Human herpesvirus 8]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:9668967] H+ [nucleoplasm]
[SimpleEntity:9668967] H+ [nucleoplasm]
precedingEvent
relatedSpecies[Species:2671781] Human herpesvirus 8
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9978311] R-HSA-9978294.1
summation[Summation:9978302] HHV8 E3 SUMO-protein ligase K8 (K-bZIP, ORFK8) is phosphoryl...
(hasEvent)[Pathway:9976073] Maturation/Activation of Immediate/Early HHV8 Proteins [Homo sapiens]
(precedingEvent)[Reaction:9978392] K8 dimer binds to ORF57 dimer [Homo sapiens]
[Reaction:9978405] K8 dimer binds to p-ORF50 tetramer [Homo sapiens]
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No pathways have been reviewed or authored by CDKs phosphorylate K8 (9978294)