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Details on Person K8 dimer moves to nucleus

Class:IdBlackBoxEvent:9978202
_displayNameK8 dimer moves to nucleus
_doReleaseFALSE
_timestamp2026-03-26 18:45:57
authored[InstanceEdit:9978177] Stephan, Ralf, 2025-12-29
compartment[Compartment:13231] nuclear envelope
created[InstanceEdit:9978199] Stephan, Ralf, 2025-12-29
disease[Disease:3134794] viral infectious disease
goBiologicalProcess[GO_BiologicalProcess:781] intracellular transport of viral protein in host cell
input[Complex:9978178] K8 dimer [cytosol] [Human herpesvirus 8]
internalReviewed[InstanceEdit:9985769] Orlic-Milacic, Marija, 2026-03-26
isChimericFALSE
literatureReference[LiteratureReference:9978196] Identification of a short amino acid sequence essential for efficient nuclear targeting of the Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 K8 protein
[LiteratureReference:9978203] Origin-independent assembly of Kaposi's sarcoma-associated herpesvirus DNA replication compartments in transient cotransfection assays and association with the ORF-K8 protein and cellular PML
modified[InstanceEdit:9983303] Stephan, Ralf, 2026-02-21
[InstanceEdit:9985311] Stephan, Ralf, 2026-03-18
[InstanceEdit:9985776] Stephan, Ralf, 2026-03-26
nameK8 dimer moves to nucleus
output[Complex:9978204] K8 dimer [nucleoplasm] [Human herpesvirus 8]
precedingEvent
relatedSpecies[Species:2671781] Human herpesvirus 8
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9978207] R-HSA-9978202.1
summation[Summation:9978189] HHV8 E3 SUMO-protein ligase K8 (K-bZIP, ORFK8) contains a nu...
(hasEvent)[Pathway:9976073] Maturation/Activation of Immediate/Early HHV8 Proteins [Homo sapiens]
(precedingEvent)[Reaction:9978209] K8 dimer auto-SUMOylates [Homo sapiens]
[Reaction:9978294] CDKs phosphorylate K8 [Homo sapiens]
[Reaction:9978809] vPK phosphorylates K8 [Homo sapiens]
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No pathways have been reviewed or authored by K8 dimer moves to nucleus (9978202)