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Details on Person Gata3, Yy1, Ets1, Pou2f1, Pou2f2, Batf, Irf4, Satb1, Smarca4 and Stat6 bind the Locus Control Region in the Rad50 gene

Class:Id	Reaction:9977982
_displayName	Gata3, Yy1, Ets1, Pou2f1, Pou2f2, Batf, Irf4, Satb1, Smarca4 and Stat6 bind the Locus Control Region in the Rad50 gene
_doRelease	TRUE
_timestamp	2026-02-26 19:19:09
authored	[InstanceEdit:9978005] May, Bruce, 2025-12-24
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9978007] May, Bruce, 2025-12-27
edited	[InstanceEdit:9978005] May, Bruce, 2025-12-24
input	[EntityWithAccessionedSequence:9977947] Ets1 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:9830515] Gata3 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:9977999] Pou2f1 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:9977949] Pou2f2 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:9978001] Rad50 gene [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:9966546] Batf [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:5619454] Yy1 [nucleoplasm] [Mus musculus] [Complex:9977972] p-Y641-Stat6 dimer [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:9966550] Irf4 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:9977987] Satb1 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:9727480] Smarca4 [nucleoplasm] [Mus musculus]
internalReviewed	[InstanceEdit:9978792] Matthews, Lisa, 2026-01-07
isChimeric	FALSE
literatureReference	[LiteratureReference:9977777] Regulation of the Th2 cytokine locus by a locus control region [LiteratureReference:9977781] Transcription Factors Oct-1 and GATA-3 Cooperatively Regulate Th2 Cytokine Gene Expression via the RHS5 within the Th2 Locus Control Region [LiteratureReference:9977943] BATF Modulates the Th2 Locus Control Region and Regulates CD4+ T Cell Fate during Antihelminth Immunity [LiteratureReference:9977988] Transcription factor YY1 is essential for regulation of the Th2 cytokine locus and for Th2 cell differentiation [LiteratureReference:9977990] Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: a target for STAT6 but not GATA3 [LiteratureReference:9978003] RHS6 coordinately regulates the Th2 cytokine genes by recruiting GATA3, SATB1, and IRF4 [LiteratureReference:9977957] SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes [LiteratureReference:9977938] BRG1-mediated chromatin remodeling regulates differentiation and gene expression of T helper cells
modified	[InstanceEdit:9979435] May, Bruce, 2026-01-19 [InstanceEdit:9983437] May, Bruce, 2026-02-24 [InstanceEdit:9983731] May, Bruce, 2026-02-26
name	Gata3, Yy1, Ets1, Pou2f1, Pou2f2, Batf, Irf4, Satb1, Smarca4 and Stat6 bind the Locus Control Region in the Rad50 gene
output	[Complex:9977961] Gata3:Yy1:Ets1:Pou2f1:Pou2f2:Batf:Irf4:Satb1:Smarca4:p-Y641-Stat6:Rad50 gene [nucleoplasm] [Mus musculus]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2026-03-25
reviewed	[InstanceEdit:9983436] Barbutti, Isabella, 2026-02-24 [InstanceEdit:9983730] Lord, Graham M, 2026-02-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9978035] R-MMU-9977982.1
summation	[Summation:9978015] The Rad50 gene is located in the 120 kb gene cluster on mous...
(inferredFrom)	[Reaction:9977764] GATA3, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 bind the Locus Control Region (LCR) in the RAD50 gene [Homo sapiens]
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No pathways have been reviewed or authored by Gata3, Yy1, Ets1, Pou2f1, Pou2f2, Batf, Irf4, Satb1, Smarca4 and Stat6 bind the Locus Control Region in the Rad50 gene (9977982)