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Details on Person Stat6, Nfatc2 (Nfat1), and Nicd1,2 bind the Gata3 gene and cause displacement of repressor complexes (Prc1, Rbpj:NcoR) by activator complexes (Mll1, Rbpj:Nicd1,2)

Class:Id	Reaction:9977960
_displayName	Stat6, Nfatc2 (Nfat1), and Nicd1,2 bind the Gata3 gene and cause displacement of repressor complexes (Prc1, Rbpj:NcoR) by activator complexes (Mll1, Rbpj:Nicd1,2)
_doRelease	TRUE
_timestamp	2026-02-26 19:19:38
authored	[InstanceEdit:9977978] May, Bruce, 2025-12-23
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9978007] May, Bruce, 2025-12-27
edited	[InstanceEdit:9977978] May, Bruce, 2025-12-23
input	[EntityWithAccessionedSequence:556795] Crebbp [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:556805] Ep300 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:2025858] p-S245-Nfatc2 [nucleoplasm] [Mus musculus] [CandidateSet:9978004] Maml [nucleoplasm] [Mus musculus] [DefinedSet:9977983] Nicd1,2 [nucleoplasm] [Mus musculus] [Complex:9977953] Mll1 complex:Men1 [nucleoplasm] [Mus musculus] [CandidateSet:9977975] mPCAF [nucleoplasm] [Mus musculus] [Complex:9977972] p-Y641-Stat6 dimer [nucleoplasm] [Mus musculus] [Complex:9977996] Prc1:Rbpj:NCoR:Gata3 gene [nucleoplasm] [Mus musculus]
internalReviewed	[InstanceEdit:9978792] Matthews, Lisa, 2026-01-07
isChimeric	FALSE
literatureReference	[LiteratureReference:9976105] STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells [LiteratureReference:9942710] Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation [LiteratureReference:9976107] Transcriptional regulation of GATA3 in T helper cells by the integrated activities of transcription factors downstream of the interleukin-4 receptor and T cell receptor [LiteratureReference:9977218] Recent advances in understanding the role of IL-4 signaling [LiteratureReference:9977594] Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells [LiteratureReference:9977600] Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch [LiteratureReference:9977768] Notch directly regulates Gata3 expression during T helper 2 cell differentiation
modified	[InstanceEdit:9979435] May, Bruce, 2026-01-19 [InstanceEdit:9983437] May, Bruce, 2026-02-24 [InstanceEdit:9983731] May, Bruce, 2026-02-26
name	Stat6, Nfatc2 (Nfat1), and Nicd1,2 bind the Gata3 gene and cause displacement of repressor complexes (Prc1, Rbpj:NcoR) by activator complexes (Mll1, Rbpj:Nicd1,2)
output	[EntityWithAccessionedSequence:573340] Hdac1 [nucleoplasm] [Mus musculus] [Complex:9977980] Mll1:Men1:p-Y641-Stat6:p-S245-Nfatc2:Notch1,2 Coactivator:Gata3 gene [nucleoplasm] [Mus musculus] [DefinedSet:9977948] Ncor1,2 [nucleoplasm] [Mus musculus] [Complex:9977973] Prc1 [nucleoplasm] [Mus musculus] [DefinedSet:2064259] Tbl1 [nucleoplasm] [Mus musculus]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2026-03-25
reviewed	[InstanceEdit:9983436] Barbutti, Isabella, 2026-02-24 [InstanceEdit:9983730] Lord, Graham M, 2026-02-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9978016] R-MMU-9977960.1
summation	[Summation:9977976] Il4 signaling via Il4ra produces phosphorylated Stat6 dimers...
(inferredFrom)	[Reaction:9976117] STAT6, NFATC2 (NFAT1), and NICD1,2 bind the GATA3 gene and cause displacement of repressor complexes (PRC1, RBPJ:NCOR) by activator complexes (MLL1, RBPJ:NICD1,2) [Homo sapiens]
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No pathways have been reviewed or authored by Stat6, Nfatc2 (Nfat1), and Nicd1,2 bind the Gata3 gene and cause displacement of repressor complexes (Prc1, Rbpj:NcoR) by activator complexes (Mll1, Rbpj:Nicd1,2) (9977960)