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Details on Person GATA3, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 bind the Locus Control Region (LCR) in the RAD50 gene

Class:Id	Reaction:9977764
_displayName	GATA3, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 bind the Locus Control Region (LCR) in the RAD50 gene
_doRelease	TRUE
_timestamp	2026-02-26 19:18:40
authored	[InstanceEdit:9977616] May, Bruce, 2025-12-22
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9977778] May, Bruce, 2025-12-23
edited	[InstanceEdit:9977616] May, Bruce, 2025-12-22
inferredFrom	[Reaction:9977982] Gata3, Yy1, Ets1, Pou2f1, Pou2f2, Batf, Irf4, Satb1, Smarca4 and Stat6 bind the Locus Control Region in the Rad50 gene [Mus musculus]
input	[EntityWithAccessionedSequence:9977776] RAD50 gene [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:1629809] ETS1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:83836] POU2F1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6814932] POU2F2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:996768] GATA3 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6789925] BATF [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:4086091] YY1 [nucleoplasm] [Homo sapiens] [Complex:6786281] p-Y641-STAT6 dimer [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:201593] SATB1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9907101] IRF4 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:201686] SMARCA4 [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9978792] Matthews, Lisa, 2026-01-07
isChimeric	FALSE
literatureReference	[LiteratureReference:9945893] T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements
modified	[InstanceEdit:9978055] May, Bruce, 2025-12-27 [InstanceEdit:9978164] May, Bruce, 2025-12-28 [InstanceEdit:9979435] May, Bruce, 2026-01-19 [InstanceEdit:9983437] May, Bruce, 2026-02-24 [InstanceEdit:9983731] May, Bruce, 2026-02-26
name	GATA3, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 bind the Locus Control Region (LCR) in the RAD50 gene
output	[Complex:9977761] GATA3:YY1:ETS1:POU2F1:POU2F2:BATF:p-Y641-STAT6:SATB1:IRF4:SMARCA4:RAD50 gene [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9976143] STAT6, NFATC2 (NFAT1), and NICD1,2 positively regulate expression of GATA3 [Homo sapiens] [Reaction:9976117] STAT6, NFATC2 (NFAT1), and NICD1,2 bind the GATA3 gene and cause displacement of repressor complexes (PRC1, RBPJ:NCOR) by activator complexes (MLL1, RBPJ:NICD1,2) [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2026-03-25
reviewed	[InstanceEdit:9983436] Barbutti, Isabella, 2026-02-24 [InstanceEdit:9983730] Lord, Graham M, 2026-02-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9977782] R-HSA-9977764.1
structureModified	[InstanceEdit:9978055] May, Bruce, 2025-12-27
summation	[Summation:9977770] The genes encoding the Th2 cytokines IL4, IL13, and IL5 are ...
(hasEvent)	[Pathway:9976102] Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9976140] GATA3, CHD4, EP300, NFATC2 (NFAT1), FOS:JUN (AP-1), KLF13, MAF, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 positively regulate expression of IL4 [Homo sapiens] [BlackBoxEvent:9976402] GATA3, CHD4, EP300, NFATC2, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 positively regulate expression of IL13 [Homo sapiens]
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No pathways have been reviewed or authored by GATA3, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 bind the Locus Control Region (LCR) in the RAD50 gene (9977764)