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Oligoadenylate synthetase 1 (OAS1) produces the second me...
| Class:Id | Summation:9977694 |
|---|---|
| _displayName | Oligoadenylate synthetase 1 (OAS1) produces the second me... |
| _timestamp | 2026-01-21 15:18:24 |
| created | [InstanceEdit:9977687] Orlic-Milacic, Marija, 2025-12-22 |
| literatureReference | [LiteratureReference:9012230] OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids [LiteratureReference:9012236] The Activation Mechanism of 2'-5'-Oligoadenylate Synthetase Gives New Insights Into OAS/cGAS Triggers of Innate Immunity [LiteratureReference:9012235] Viral encounters with 2',5'-oligoadenylate synthetase and RNase L during the interferon antiviral response [LiteratureReference:8983650] Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1 [LiteratureReference:9977696] Rotavirus Controls Activation of the 2'-5'-Oligoadenylate Synthetase/RNase L Pathway Using at Least Two Distinct Mechanisms |
| modified | [InstanceEdit:9977708] Orlic-Milacic, Marija, 2025-12-22 [InstanceEdit:9979785] Orlic-Milacic, Marija, 2026-01-21 |
| text | Oligoadenylate synthetase 1 (OAS1) produces the second messenger 5’-triphosphorylated 2'-5'-oligoadenylate (2-5A), which limits viral propagation through the activation of the enzyme RNase L (reviewed by Silverman 2007; Hornung et al. 2014). OAS1 produces 2-5A from ATP by transferring an AMP unit from the AMP donor substrate (ATP) to the 2′-hydroxyl group of an AMP acceptor substrate, ATP or a preformed 2-5A oligomer (Lohofener et al. 2015). This produces a 2-5A dimer (ppp5'A(2'-5')A) or an elongated 2-5A oligomer (ppp5'A((2'-5')A)n), as well as one molecule of pyrophosphate (PPi) for each AMP residue added (Lohofener et al. 2015). Structural studies showed that RNA-induced conformational rearrangement in OAS1 positions the active site residues D75, D77, and D148 compactly for coordination of two Mg2+ ions and for binding of ATP (Donovan et al. 2013). The assembly of this critical active-site structure of OAS1 provides the gate that couples binding of dsRNA to the production and downstream functions of 2-5A, enabling OAS1 to function as a sensor of double-stranded RNA (dsRNA) (Donovan et al. 2013). Rotavirus A (RV-A) dsRNAs are recognized by OAS. Knockdown of OAS1 significantly increases infectivity of the simian RV-A strain RRV in monkey kidney cell line MA104, while knockdown of OAS3 has no effect (Sánchez-Tacuba et al. 2015). |
| (summation) | [BlackBoxEvent:9977697] RV-A-activated OAS1 produces oligoadenylates [Homo sapiens] |
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Oligoadenylate synthetase 1 (OAS1) produces the second me... (9977694)
