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Details on Person Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells
| Class:Id | LiteratureReference:9977594 |
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| _displayName | Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells |
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| _timestamp | 2025-12-22 14:23:38 |
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| author | [Person:8863851] Amsen, Derk
[Person:8863922] Blander, J Magarian
[Person:9945257] Lee, Gap Ryol
[Person:9977601] Tanigaki, Kenji
[Person:164925] Honjo, Tasuku
[Person:6783273] Flavell, Richard A |
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| created | [InstanceEdit:9977602] May, Bruce, 2025-12-22 |
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| journal | Cell |
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| pages | 515-26 |
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| pubMedIdentifier | 15137944 |
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| title | Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells |
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| volume | 117 |
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| year | 2004 |
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| (literatureReference) | [RegulationReference:9977971] Positive gene expression regulation by 'Mll1:Men1:p-Y641-Stat6:p-S245-Nfatc2:Notch1,2 Coactivator:Gata3 gene [nucleoplasm]' STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells
[Pathway:9976102] Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) [Homo sapiens]
[Reaction:9977960] Stat6, Nfatc2 (Nfat1), and Nicd1,2 bind the Gata3 gene and cause displacement of repressor complexes (Prc1, Rbpj:NcoR) by activator complexes (Mll1, Rbpj:Nicd1,2) [Mus musculus]
[BlackBoxEvent:9977991] Stat6, Nfatc2, and Nicd1,2 positiively regulate expression of Gata3 [Mus musculus]
[Summation:9976113] IL4 signaling via IL4RA produces phosphorylated STAT6 dimers...
[Summation:9977219] IL4 signaling produces phosphorylated STAT6 dimers and T cel... |
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