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Details on Person RV-A stimulates P2RY1 activation

Class:Id	Reaction:9977333
_displayName	RV-A stimulates P2RY1 activation
_timestamp	2026-01-21 15:44:21
authored	[InstanceEdit:9979788] Orlic-Milacic, Marija, 2026-01-21
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9977332] Orlic-Milacic, Marija, 2025-12-18
disease	[Disease:3134794] viral infectious disease
input	[EntityWithAccessionedSequence:391956] P2RY1 [plasma membrane] [Homo sapiens] [SimpleEntity:114564] ADP [extracellular region]
modified	[InstanceEdit:9977366] Orlic-Milacic, Marija, 2025-12-18 [InstanceEdit:9977375] Orlic-Milacic, Marija, 2025-12-18 [InstanceEdit:9977422] Orlic-Milacic, Marija, 2025-12-19 [InstanceEdit:9977592] Orlic-Milacic, Marija, 2025-12-22 [InstanceEdit:9979789] Orlic-Milacic, Marija, 2026-01-21
name	RV-A stimulates P2RY1 activation
output	[Complex:417920] P2RY1:ADP [plasma membrane] [Homo sapiens]
participantCellType	[PhysicalEntityCellType:9977368] P2RY1 [plasma membrane] in enterocyte of epithelium of intestinal villus [PhysicalEntityCellType:9977371] P2RY1:ADP [plasma membrane] in enterocyte of epithelium of intestinal villus [PhysicalEntityCellType:9977580] NSP4 tetramer [endoplasmic reticulum membrane] in rotavirus-infected enterocyte of epithelium of intestinal villus
precedingEvent	[BlackBoxEvent:9977334] RV-A increased cytosolic Ca2+ promotes release of extracellular ADP [Homo sapiens] [Reaction:9977273] Calcium release from intracellular stores by RV-A viroporin NSP4 [Homo sapiens] [BlackBoxEvent:9978817] NSP4 triggers calcium influx into RV-A infected cells [Homo sapiens]
regulatedBy	[PositiveRegulation:9977331] Positive regulation by 'NSP4 tetramer [endoplasmic reticulum membrane]'
relatedSpecies	[Species:9615053] Rotavirus A
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9977335] R-HSA-9977333.1
summation	[Summation:9977352] ADP released from cells infected with rotavirus A (RV-A) act...
(hasEvent)	[Pathway:9974192] Rotavirus A (RV-A) host interactions [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9977415] RV-A-activated P2RY1 triggers intercellular calcium waves [Homo sapiens]
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No pathways have been reviewed or authored by RV-A stimulates P2RY1 activation (9977333)