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Details on Person HHV8 Replication and transcription activator (ORF50, RTA) lo...
| Class:Id | Summation:9976964 |
|---|---|
| _displayName | HHV8 Replication and transcription activator (ORF50, RTA) lo... |
| _timestamp | 2026-03-21 09:44:10 |
| created | [InstanceEdit:9976972] Stephan, Ralf, 2025-12-16 |
| modified | [InstanceEdit:9985624] Stephan, Ralf, 2026-03-21 |
| text | HHV8 Replication and transcription activator (ORF50, RTA) localizes to the nucleus. ORF50 has two putative nuclear localization sequence (NLS) motifs, and it has been established in human and monkey cells that the NLS2 is required and sufficient for ORF50 nuclear localization (Bu et al., 2008). The process is promoted by RNF31-mediated linear ubiquitination (Luan et al., 2024) and inhibited by phosphoribosylformyl-glycinamidine synthetase (PFAS)-mediated deamination of ORF50 asparagine residues (Li et al., 2019) or by removal of M1-polyUb modifications by host Ubiquitin thioesterase OTULIN (Luan et al., 2024). |
| (summation) | [BlackBoxEvent:9976969] ORF50 tetramer localizes to nucleus [Homo sapiens] |
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No pathways have been reviewed or authored by HHV8 Replication and transcription activator (ORF50, RTA) lo... (9976964)
