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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person ORF50 forms homotetramers

Class:IdReaction:9976854
_displayNameORF50 forms homotetramers
_doReleaseFALSE
_timestamp2026-03-26 18:47:01
authored[InstanceEdit:9976837] Stephan, Ralf, 2025-12-15
compartment[Compartment:70101] cytosol
created[InstanceEdit:9976851] Stephan, Ralf, 2025-12-15
disease[Disease:3134794] viral infectious disease
goBiologicalProcess[GO_BiologicalProcess:160867] protein homooligomerization
input[EntityWithAccessionedSequence:9976790] OGlcNAc-T366,T367-M1polyUb-K516,K518-ORF50 [cytosol] [Human herpesvirus 8]
[EntityWithAccessionedSequence:9976790] OGlcNAc-T366,T367-M1polyUb-K516,K518-ORF50 [cytosol] [Human herpesvirus 8]
[EntityWithAccessionedSequence:9976790] OGlcNAc-T366,T367-M1polyUb-K516,K518-ORF50 [cytosol] [Human herpesvirus 8]
[EntityWithAccessionedSequence:9976790] OGlcNAc-T366,T367-M1polyUb-K516,K518-ORF50 [cytosol] [Human herpesvirus 8]
internalReviewed[InstanceEdit:9985769] Orlic-Milacic, Marija, 2026-03-26
isChimericFALSE
literatureReference[LiteratureReference:9976847] Kaposi's sarcoma-associated herpesvirus Rta tetramers make high-affinity interactions with repetitive DNA elements in the Mta promoter to stimulate DNA binding of RBP-Jk/CSL
[LiteratureReference:9976843] Electron microscopy mapping of the DNA-binding sites of monomeric, dimeric, and multimeric KSHV RTA protein
[LiteratureReference:9976844] Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50/Rta lytic switch protein functions as a tetramer
[LiteratureReference:9977099] Regulation of the Abundance of Kaposi's Sarcoma-Associated Herpesvirus ORF50 Protein by Oncoprotein MDM2
modified[InstanceEdit:9977102] Stephan, Ralf, 2025-12-17
[InstanceEdit:9977815] Stephan, Ralf, 2025-12-23
[InstanceEdit:9983303] Stephan, Ralf, 2026-02-21
[InstanceEdit:9985311] Stephan, Ralf, 2026-03-18
[InstanceEdit:9985776] Stephan, Ralf, 2026-03-26
nameORF50 forms homotetramers
output[Complex:9976849] ORF50 tetramer [cytosol] [Human herpesvirus 8]
precedingEvent
relatedSpecies[Species:2671781] Human herpesvirus 8
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9976855] R-HSA-9976854.1
summation[Summation:9976845] Recombinant HHV8 Replication and transcription activator (OR...
(hasEvent)[Pathway:9976073] Maturation/Activation of Immediate/Early HHV8 Proteins [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9976969] ORF50 tetramer localizes to nucleus [Homo sapiens]
[Reaction:9982293] ORF75 binds to ORF50 and PFAS [Homo sapiens]
[BlackBoxEvent:9985224] ORF50 polyubiquitinates TRIM32 [Homo sapiens]
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No pathways have been reviewed or authored by ORF50 forms homotetramers (9976854)
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