Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person Diagram of Maturation/Activation of Immediate/Early HHV8 Proteins

Class:IdPathwayDiagram:9976730
_displayNameDiagram of Maturation/Activation of Immediate/Early HHV8 Proteins
_timestamp2026-04-25 17:47:43
created[InstanceEdit:9976731] Stephan, Ralf, 2025-12-13
height1332
modified[InstanceEdit:9976784] Stephan, Ralf, 2025-12-14
[InstanceEdit:9976796] Stephan, Ralf, 2025-12-14
[InstanceEdit:9976814] Stephan, Ralf, 2025-12-14
[InstanceEdit:9976837] Stephan, Ralf, 2025-12-15
[InstanceEdit:9976851] Stephan, Ralf, 2025-12-15
[InstanceEdit:9976972] Stephan, Ralf, 2025-12-16
[InstanceEdit:9977090] Stephan, Ralf, 2025-12-17
[InstanceEdit:9977102] Stephan, Ralf, 2025-12-17
[InstanceEdit:9977260] Stephan, Ralf, 2025-12-18
[InstanceEdit:9977382] Stephan, Ralf, 2025-12-19
[InstanceEdit:9977407] Stephan, Ralf, 2025-12-19
[InstanceEdit:9977489] Stephan, Ralf, 2025-12-21
[InstanceEdit:9977508] Stephan, Ralf, 2025-12-21
[InstanceEdit:9977554] Stephan, Ralf, 2025-12-22
[InstanceEdit:9977561] Stephan, Ralf, 2025-12-22
[InstanceEdit:9977789] Stephan, Ralf, 2025-12-23
[InstanceEdit:9977809] Stephan, Ralf, 2025-12-23
[InstanceEdit:9977813] Stephan, Ralf, 2025-12-23
[InstanceEdit:9977859] Stephan, Ralf, 2025-12-24
[InstanceEdit:9977879] Stephan, Ralf, 2025-12-24
[InstanceEdit:9977893] Stephan, Ralf, 2025-12-25
[InstanceEdit:9977902] Stephan, Ralf, 2025-12-25
[InstanceEdit:9977919] Stephan, Ralf, 2025-12-26
[InstanceEdit:9977930] Stephan, Ralf, 2025-12-26
[InstanceEdit:9978076] Stephan, Ralf, 2025-12-27
[InstanceEdit:9978086] Stephan, Ralf, 2025-12-27
[InstanceEdit:9978159] Stephan, Ralf, 2025-12-28
[InstanceEdit:9978177] Stephan, Ralf, 2025-12-29
[InstanceEdit:9978199] Stephan, Ralf, 2025-12-29
[InstanceEdit:9978211] Stephan, Ralf, 2025-12-29
[InstanceEdit:9978309] Stephan, Ralf, 2025-12-30
[InstanceEdit:9978400] Stephan, Ralf, 2025-12-31
[InstanceEdit:9978406] Stephan, Ralf, 2025-12-31
[InstanceEdit:9978455] Stephan, Ralf, 2026-01-01
[InstanceEdit:9978474] Stephan, Ralf, 2026-01-01
[InstanceEdit:9978665] Stephan, Ralf, 2026-01-04
[InstanceEdit:9979402] Stephan, Ralf, 2026-01-19
[InstanceEdit:9980133] Stephan, Ralf, 2026-01-25
[InstanceEdit:9981924] Stephan, Ralf, 2026-02-12
[InstanceEdit:9981928] Stephan, Ralf, 2026-02-12
[InstanceEdit:9982296] Stephan, Ralf, 2026-02-16
[InstanceEdit:9982309] Stephan, Ralf, 2026-02-16
[InstanceEdit:9983392] Stephan, Ralf, 2026-02-23
[InstanceEdit:9984987] Stephan, Ralf, 2026-03-13
[InstanceEdit:9985625] Stephan, Ralf, 2026-03-21
[InstanceEdit:9985626] Stephan, Ralf, 2026-03-22
[InstanceEdit:9985664] Stephan, Ralf, 2026-03-24
[InstanceEdit:9987677] Stephan, Ralf, 2026-04-25
representedPathway[Pathway:9976073] Maturation/Activation of Immediate/Early HHV8 Proteins [Homo sapiens]
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<displayName>UDP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="1021" reactomeId="9687814" position="428 1046" bounds="400 1031 57 31" textPosition="411 1035"> <Properties> <displayName>OGT</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1040" reactomeId="9978178" position="705 1105" bounds="674 1093 63 25" textPosition="677 1096" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>K8 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1059" reactomeId="9978204" position="908 1103" bounds="877 1091 63 25" textPosition="880 1094" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableEntitySet id="1090" reactomeId="3899312" position="908 1042" bounds="857 1019 103 46" textPosition="864 1024"> <Properties> <displayName>UBE2I:SUMO2,UBE2I:SUMO3</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1091" reactomeId="9978218" position="1139 1064" bounds="1103 1046 72 36" textPosition="1108 1046" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SUMO-K8 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1092" reactomeId="912481" position="1134 1109" bounds="1111 1097 46 25" textPosition="1113 1098"> <Properties> <displayName>UBE2I</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="1132" reactomeId="29358" position="916 1203" bounds="896 1188 40 31" textPosition="900 1192"> <Properties> <displayName>ATP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1133" reactomeId="113582" position="1204 1218" bounds="1184 1203 40 31" textPosition="1188 1207"> <Properties> <displayName>ADP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="1134" reactomeId="9978305" position="1223 1165" bounds="1180 1147 86 37" textPosition="1182 1148" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-T111,S167-K8 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1137" reactomeId="9668967" position="1093 1219" bounds="1078 1205 31 28" textPosition="1081 1208"> <Properties> <displayName>H+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="1159" reactomeId="9978395" position="1333 923" bounds="1301 900 64 47" textPosition="1303 897" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>K8 dimer:ORF57 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1169" reactomeId="9978399" position="1187 972" bounds="1148 953 78 38" textPosition="1151 954"> <Properties> <displayName>p-K8,SUMO-K8 dimers</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1184" reactomeId="9978402" position="1511 825" bounds="1480 800 63 50" textPosition="1482 800" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>K8 dimer:p-ORF50 tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1186" reactomeId="9978461" position="1259 316" bounds="1246 304 26 25" textPosition="1248 305"> <Properties> <displayName>K2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="1187" reactomeId="9978462" position="1398 318" bounds="1341 299 115 39" textPosition="1343 300"> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.1391304347826087" relativeY="0.0" label="Gl" trackId="0" reactomeId="9978448" /> <org.gk.render.RenderableFeature relativeX="0.2782608695652174" relativeY="0.0" label="Gl" trackId="0" reactomeId="9978458" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="1203" reactomeId="9973362" position="1711 25" bounds="1653 6 117 39" textPosition="1656 7"> <Properties> <displayName>high mannose-N-glycan-N78,N89-K2</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.0" relativeY="0.8355528167574664" label="Gl" trackId="0" reactomeId="9978448" /> <org.gk.render.RenderableFeature relativeX="0.0" relativeY="0.5729431109242281" label="Gl" trackId="0" reactomeId="9978458" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.ProcessNode id="1204" reactomeId="9976071" position="1750 716" bounds="1669 683 163 67" textPosition="1673 687"> <Properties> <displayName>Maturation/Activation of Delayed Early Lytic HHV8 Proteins</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableChemical id="1207" reactomeId="113592" position="674 877" bounds="653 862 42 31" textPosition="658 866" /> <org.gk.render.RenderableChemical id="1208" reactomeId="29370" position="455 880" bounds="434 865 42 31" textPosition="439 869" /> <org.gk.render.RenderableProtein id="1209" reactomeId="9977796" position="427 922" bounds="402 900 50 45" textPosition="404 898"> <Properties> <displayName>p-S41,S162-ORF45</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="1.0" relativeY="0.6118522121802209" label="P" trackId="0" reactomeId="9977798" /> <org.gk.render.RenderableFeature relativeX="0.0" relativeY="0.10750538415796163" label="P" trackId="0" reactomeId="9977786" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="1210" reactomeId="9730454" position="586 844" bounds="525 825 122 39" textPosition="527 826"> <Properties> <displayName>p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="1212" reactomeId="70106" position="483 847" bounds="470 833 27 28" textPosition="471 836" /> <org.gk.render.RenderableComplex id="1213" reactomeId="9982291" position="769 383" bounds="724 364 90 39" textPosition="725 367" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ORF75:ORF50 tetramer:PFAS</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="1214" reactomeId="9976070" position="1091 383" bounds="1020 349 143 69" textPosition="1022 354"> <Properties> <displayName>Maturation/Activation of Late HHV8 Lytic Proteins</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableComplex id="1216" reactomeId="9982308" position="1490 194" bounds="1460 182 61 25" textPosition="1464 185" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>K5:PLP2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1218" reactomeId="5216106" position="1373 134" bounds="1350 122 46 25" textPosition="1355 123"> <Properties> <displayName>PLP2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1381" reactomeId="9931406" position="326 532" bounds="311 521 31 23" textPosition="311 522" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CK2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1402" reactomeId="9984977" position="903 617" bounds="876 599 55 36" textPosition="879 599" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ORF50:NCOA2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="1403" reactomeId="9976097" position="86 480" bounds="18 454 137 53" textPosition="17 458"> <Properties> <displayName>Establishment of Lytic HHV8 Infection</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableComplex id="1405" reactomeId="6804933" position="967 528" bounds="926 509 82 39" textPosition="927 512" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-S166,S188-MDM2 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1448" reactomeId="9985627" position="1018 1218" bounds="975 1200 87 37" textPosition="977 1200"> <Properties> <displayName>CDK1:CCNB,CDK2:CCNA,E</displayName> </Properties> </org.gk.render.RenderableEntitySet> </Nodes> <Edges> <org.gk.render.RenderableReaction id="7" reactomeId="9976718" points="396 203, 430 202, 465 203" position="430 202" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="4" points="352 240" /> <Input id="5" points="349 204" /> </Inputs> <Outputs> <Output id="6" points="519 203" /> <Output id="8" points="482 219" /> <Output id="9" points="468 240" /> </Outputs> <Catalysts> <Catalyst id="3" points="430 155" /> </Catalysts> <Properties> <displayName>OGT O-glycosylates ORF50</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="49" reactomeId="9976781" points="633 201, 673 201, 716 200" position="673 201" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="6" /> </Inputs> <Outputs> <Output id="50" /> </Outputs> <Catalysts> <Catalyst id="60" points="672 157" /> </Catalysts> <Properties> <displayName>RNF31 M1-polyubiquitinates ORF50</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="87" reactomeId="9976808" points="626 308, 627 328, 627 353" position="627 328" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="88" stoichiometry="2" points="649 275" /> <Input id="6" points="584 225" /> </Inputs> <Outputs> <Output id="89" points="628 399" /> <Output id="90" stoichiometry="2" points="584 369" /> </Outputs> <Catalysts> <Catalyst id="91" points="699 328" /> </Catalysts> <Inhibitors> <Inhibitor id="1213" points="721 365" /> </Inhibitors> <Properties> <displayName>PFAS deamidates ORF50</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="118" reactomeId="9976836" points="484 337, 465 366, 442 400" position="465 366" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="119" points="465 330" /> <Input id="6" points="563 225" /> </Inputs> <Outputs> <Output id="120" /> </Outputs> <Catalysts> <Catalyst id="6" points="570 225, 531 342" /> </Catalysts> <Properties> <displayName>GlcNAc-ORF50 auto-polyubiquitinates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="138" reactomeId="9976854" points="842 199, 899 199, 942 200" position="899 199" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="50" stoichiometry="4" /> </Inputs> <Outputs> <Output id="139" /> </Outputs> <Properties> <displayName>ORF50 forms homotetramers</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="559" reactomeId="9976969" points="978 224, 981 426, 1067 524" position="981 426" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="139" /> </Inputs> <Outputs> <Output id="560" /> </Outputs> <Inhibitors> <Inhibitor id="89" points="690 426" /> </Inhibitors> <Activators> <Activator id="50" points="801 229" /> <Activator id="1213" points="817 392" /> </Activators> <Properties> <displayName>ORF50 tetramer localizes to nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="562" reactomeId="9977088" points="716 213, 673 223, 633 214" position="673 223" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="50" /> </Inputs> <Outputs> <Output id="6" /> </Outputs> <Catalysts> <Catalyst id="563" points="714 253" /> </Catalysts> <Properties> <displayName>OTULIN deubiquitinates ORF50</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="593" reactomeId="9977103" points="1068 565, 1041 597, 1007 642" position="1041 597" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="560" /> </Inputs> <Outputs> <Output id="594" /> </Outputs> <Catalysts> <Catalyst id="1405" points="987 551" /> </Catalysts> <Inhibitors> <Inhibitor id="1402" points="934 613" /> </Inhibitors> <Properties> <displayName>MDM2 polyubiquitinates ORF50</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="599" reactomeId="9977258" points="1081 672, 1081 697, 1029 728" position="1081 697" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="560" points="1081 565" /> <Input id="600" points="1111 651" /> </Inputs> <Outputs> <Output id="601" /> </Outputs> <Catalysts> <Catalyst id="602" points="1125 696" /> </Catalysts> <Properties> <displayName>PARP1 poly(ADP)-ribosylates ORF50</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="632" reactomeId="9977381" points="1237 606, 1266 629, 1265 658" position="1266 629" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="560" points="1115 556" /> <Input id="633" stoichiometry="8" points="1237 587" /> </Inputs> <Outputs> <Output id="634" points="1266 716" /> <Output id="635" stoichiometry="8" points="1245 671" /> <Output id="636" stoichiometry="8" points="1295 675" /> </Outputs> <Catalysts> <Catalyst id="637" points="1332 613" /> </Catalysts> <Properties> <displayName>CDK9 phosphorylates ORF50</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="668" reactomeId="9977412" points="1276 230, 1851 230, 1850 47" position="1851 230" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="654" /> </Inputs> <Outputs> <Output id="676" /> </Outputs> <Properties> <displayName>K6 is secreted</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="677" reactomeId="9977485" points="1275 270, 1808 270, 1808 48" position="1808 270" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="678" /> </Inputs> <Outputs> <Output id="679" /> </Outputs> <Properties> <displayName>K4 is secreted</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="691" reactomeId="9977505" points="1382 467, 1382 499, 1382 543" position="1382 499" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="692" /> </Inputs> <Outputs> <Output id="693" /> </Outputs> <Properties> <displayName>ORF11 moves to nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="739" reactomeId="9977567" points="1479 395, 1537 395, 1582 395" position="1537 395" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="716" /> </Inputs> <Outputs> <Output id="740" /> </Outputs> <Properties> <displayName>vBCL2 moves to mitochondria</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="788" reactomeId="9977806" points="707 924, 810 936, 858 926" position="810 936" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="760" /> </Inputs> <Outputs> <Output id="789" /> </Outputs> <Properties> <displayName>ORF45 moves to nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="804" reactomeId="9977812" points="858 914, 809 898, 707 917" position="809 898" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="789" /> </Inputs> <Outputs> <Output id="760" /> </Outputs> <Properties> <displayName>ORF45 is exported from nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="849" reactomeId="9977857" points="309 599, 326 599, 344 600" position="326 599" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="850" points="269 599" /> <Input id="851" stoichiometry="3" points="292 659" /> </Inputs> <Outputs> <Output id="852" points="390 601" /> <Output id="853" stoichiometry="3" points="403 653" /> <Output id="856" stoichiometry="3" points="363 641" /> </Outputs> <Catalysts> <Catalyst id="1381" points="326 547" /> </Catalysts> <Properties> <displayName>CK2 phosphorylates ORF57</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="857" reactomeId="9977862" points="525 601, 564 602, 601 601" position="564 602" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="858" stoichiometry="2" points="515 631" /> <Input id="852" points="490 601" /> </Inputs> <Outputs> <Output id="859" points="670 600" /> <Output id="860" stoichiometry="2" points="664 637" /> <Output id="764" stoichiometry="2" points="632 633" /> </Outputs> <Catalysts> <Catalyst id="861" points="565 662" /> </Catalysts> <Properties> <displayName>Unknown kinase phosphorylates ORF57</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="885" reactomeId="9977877" points="729 705, 729 727, 730 761" position="729 727" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="886" stoichiometry="2" points="758 680" /> <Input id="859" stoichiometry="2" points="729 622" /> </Inputs> <Outputs> <Output id="887" /> </Outputs> <Properties> <displayName>p-ORF57 dimerizes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="902" reactomeId="9977897" points="760 797, 812 828, 878 827" position="812 828" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="887" /> </Inputs> <Outputs> <Output id="903" /> </Outputs> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="921" reactomeId="9977904" points="971 906, 971 907, 971 956" position="971 907" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="922" points="1006 880" /> <Input id="903" points="923 849" /> </Inputs> <Outputs> <Output id="923" /> </Outputs> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="944" reactomeId="9977925" points="1229 826, 1229 826, 1287 825" position="1229 826" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="634" points="1259 758" /> <Input id="903" points="941 826" /> </Inputs> <Outputs> <Output id="945" /> </Outputs> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="963" reactomeId="9977928" points="267 780, 324 780, 368 780" position="324 780" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="964" stoichiometry="2" /> </Inputs> <Outputs> <Output id="965" /> </Outputs> <Properties> <displayName>ORF70 forms dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1008" reactomeId="9978090" points="1479 117, 1479 99, 1479 64" position="1479 99" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="1009" /> </Inputs> <Outputs> <Output id="1010" /> </Outputs> <Properties> <displayName>K5 localizes to plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1011" reactomeId="9978150" points="404 1109, 429 1108, 455 1108" position="429 1108" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="1012" points="372 1109" /> <Input id="1015" points="370 1142" /> </Inputs> <Outputs> <Output id="1013" points="489 1108" /> <Output id="1017" points="471 1129" /> <Output id="1019" points="484 1077" /> </Outputs> <Catalysts> <Catalyst id="1021" points="428 1065" /> </Catalysts> <Properties> <displayName>OGT O-glycosylates K8</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1039" reactomeId="9978175" points="568 1107, 627 1105, 671 1105" position="627 1105" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="1013" stoichiometry="2" /> </Inputs> <Outputs> <Output id="1040" /> </Outputs> <Properties> <displayName>GlcNAc-K8 dimerizes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1058" reactomeId="9978202" points="740 1104, 810 1103, 874 1103" position="810 1103" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="1040" /> </Inputs> <Outputs> <Output id="1059" /> </Outputs> <Properties> <displayName>K8 dimer moves to nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1089" reactomeId="9978209" points="1015 1071, 1039 1071, 1062 1071" position="1039 1071" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="1090" stoichiometry="4" points="966 1055" /> <Input id="1059" points="943 1093" /> </Inputs> <Outputs> <Output id="1091" points="1100 1067" /> <Output id="1092" stoichiometry="4" points="1110 1094" /> </Outputs> <Catalysts> <Catalyst id="1059" points="943 1102, 1011 1101" /> </Catalysts> <Inhibitors> <Inhibitor id="1134" points="1177 1156, 1073 1136" /> </Inhibitors> <Properties> <displayName>K8 dimer auto-SUMOylates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1131" reactomeId="9978294" points="989 1170, 1020 1170, 1052 1170" position="1020 1170" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="1132" stoichiometry="2" points="939 1193" /> <Input id="1059" points="923 1119" /> </Inputs> <Outputs> <Output id="1133" stoichiometry="2" points="1181 1211" /> <Output id="1134" points="1177 1166" /> <Output id="1137" stoichiometry="2" points="1081 1202" /> </Outputs> <Catalysts> <Catalyst id="1448" points="1018 1194" /> </Catalysts> <Properties> <displayName>CDKs phosphorylate K8</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1158" reactomeId="9978392" points="1262 922, 1262 923, 1298 923" position="1262 923" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="903" points="941 830, 1096 850" /> <Input id="1169" points="1215 947" /> </Inputs> <Outputs> <Output id="1159" /> </Outputs> <Properties> <displayName>K8 dimer binds to ORF57 dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="1170" points="1148 1043, 1176 997" position="1162 1020" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1091" /> </Inputs> <Outputs> <Output id="1169" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1171" points="1219 1144, 1190 997" position="1204 1070" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1134" /> </Inputs> <Outputs> <Output id="1169" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="1183" reactomeId="9978405" points="1427 825, 1426 825, 1477 825" position="1426 825" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="1169" points="1232 971, 1381 971" /> <Input id="634" points="1301 754" /> </Inputs> <Outputs> <Output id="1184" /> </Outputs> <Properties> <displayName>K8 dimer binds to p-ORF50 tetramer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1185" reactomeId="9978457" points="1275 315, 1308 315, 1338 316" position="1308 315" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="1186" /> </Inputs> <Outputs> <Output id="1187" /> </Outputs> <Properties> <displayName>K2 is N-glycosylated</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1202" reactomeId="9978469" points="1459 317, 1713 314, 1711 48" position="1713 314" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="1187" /> </Inputs> <Outputs> <Output id="1203" /> </Outputs> <Properties> <displayName>Glycosylated K2 is secreted</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1205" interactionType="Activate" points="941 823, 1666 726" position="1303 774" lineWidth="2.0"> <Inputs> <Input id="903" /> </Inputs> <Outputs> <Output id="1204" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1206" reactomeId="9977793" points="610 922, 585 922, 512 921" position="585 922" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="1207" stoichiometry="2" points="650 891" /> <Input id="760" points="649 922" /> </Inputs> <Outputs> <Output id="1208" stoichiometry="2" points="479 895" /> <Output id="1209" points="455 921" /> <Output id="1212" stoichiometry="2" points="488 864" /> </Outputs> <Catalysts> <Catalyst id="1210" points="585 870" /> </Catalysts> <Properties> <displayName>TBK1/IKBKE phosphorylate ORF45</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1215" interactionType="Activate" points="1017 383, 817 383" position="917 383" lineWidth="2.0"> <Inputs> <Input id="1214" /> </Inputs> <Outputs> <Output id="1213" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1217" reactomeId="9982307" points="1435 170, 1435 170, 1461 179" position="1435 170" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="1009" points="1464 143" /> <Input id="1218" points="1394 150" /> </Inputs> <Outputs> <Output id="1216" /> </Outputs> <Properties> <displayName>K5 binds to PLP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1404" interactionType="Activate" points="158 478, 757 470, 885 596" position="757 470" lineWidth="2.0"> <Inputs> <Input id="1403" /> </Inputs> <Outputs> <Output id="1402" /> </Outputs> </org.gk.render.RenderableInteraction> </Edges> <Pathways /> </Process>
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