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Details on Person RV-A DLPs bud into rough endoplasmic reticulum

Class:Id	BlackBoxEvent:9976573
_displayName	RV-A DLPs bud into rough endoplasmic reticulum
_doRelease	FALSE
_timestamp	2026-01-21 18:59:35
authored	[InstanceEdit:9979788] Orlic-Milacic, Marija, 2026-01-21
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol [Compartment:171242] viral envelope [Compartment:6490] viral tegument
created	[InstanceEdit:9976607] Orlic-Milacic, Marija, 2025-12-12
disease	[Disease:3134794] viral infectious disease
input	[Complex:9976490] RV-A DLP:NSP4 tetramer [endoplasmic reticulum membrane] [Rotavirus A] [EntityWithAccessionedSequence:9965406] VP4 [cytosol] [Rotavirus A] [Complex:9821530] VP7 trimer [endoplasmic reticulum membrane] [Rotavirus A]
isChimeric	FALSE
modified	[InstanceEdit:9976701] Orlic-Milacic, Marija, 2025-12-12 [InstanceEdit:9979789] Orlic-Milacic, Marija, 2026-01-21 [InstanceEdit:9979801] Orlic-Milacic, Marija, 2026-01-21
name	RV-A DLPs bud into rough endoplasmic reticulum
output	[Complex:9976570] RV-A DLP:NSP4 tetramer [viral envelope] [Rotavirus A] [Complex:9976585] VP7 trimer [viral envelope] [Rotavirus A] [EntityWithAccessionedSequence:9976611] VP4 [viral tegument] [Rotavirus A]
precedingEvent	[Reaction:9976489] VP6 on DLPs attaches to NSP4 [Homo sapiens] [Reaction:9973104] Formation of RV-A double-layered particle (DLP) [Homo sapiens] [BlackBoxEvent:9821724] NSP4 forms a tetramer [Homo sapiens] [BlackBoxEvent:9965286] Translation of RV-A VP4 [Homo sapiens] [Reaction:9966113] NSP3 binds eIF4G [Homo sapiens] [BlackBoxEvent:9960591] Release of RV-A capped mRNAs from DLPs to cytosol [Homo sapiens] [Reaction:9821512] Glycosylated VP7 forms a trimer [Homo sapiens] [BlackBoxEvent:9821541] VP7 is N-glycosylated [Homo sapiens] [BlackBoxEvent:9976472] VP7 folding and formation of disulfide bonds [Homo sapiens]
relatedSpecies	[Species:9615053] Rotavirus A
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9976653] R-HSA-9976573.1
summation	[Summation:9976696] Using a reassortant rotavirus A (RV-A) between the human str...
(hasEvent)	[Pathway:9819331] Genome Replication, Assembly and Release of Rotavirus A (RV-A) triple-layer particles (TLPs) [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9976160] Formation of RV-A triple layer particles [Homo sapiens]
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No pathways have been reviewed or authored by RV-A DLPs bud into rough endoplasmic reticulum (9976573)