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Details on Person Mannose residues in the attached N-glycan of VP7 were report...
| Class:Id | Summation:9976469 |
|---|---|
| _displayName | Mannose residues in the attached N-glycan of VP7 were report... |
| _timestamp | 2026-01-20 14:32:54 |
| created | [InstanceEdit:9976470] Orlic-Milacic, Marija, 2025-12-11 |
| literatureReference | [LiteratureReference:9821544] Processing of the rough endoplasmic reticulum membrane glycoproteins of rotavirus SA11 [LiteratureReference:9932574] Roles of N-linked glycans in the endoplasmic reticulum |
| modified | [InstanceEdit:9979637] Orlic-Milacic, Marija, 2026-01-20 |
| text | Mannose residues in the attached N-glycan of VP7 were reported to get trimmed to Man8GlcNAc2, Man6GlcNAc2, and finally to Man5GlcNAc2 during virion assembly (Kabnecell and Atkinson 1985). Normally, mannose trimming in the endoplasmic reticulum (ER), performed by the endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, also known as MAN1B1, is known to occur on glycosylated proteins that do not pass the ER quality control and is the trigger for their degradation (reviewed in Helenius and Aebi 2004). Mannose trimming may contribute to retention of VP7 in the ER, preventing its translocation to the Golgi apparatus. As mannose trimming in VP7 was not studied further, Man8GlcNAc2-VP7 is annotated as the final trimming product. There is evidence that trimming may occur even after VP7 is incorporated into virions during the assembly process (Kabnecell and Atkinson 1985). |
| (summation) | [BlackBoxEvent:9976456] Endoplasmic reticulum mannosidase trims terminal mannose from Man9GlcNAc2-VP7 [Homo sapiens] |
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