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Details on Person GATA3, CHD4, EP300, NFATC2, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 positively regulate expression of IL13

Class:Id	BlackBoxEvent:9976402
_displayName	GATA3, CHD4, EP300, NFATC2, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 positively regulate expression of IL13
_doRelease	TRUE
_timestamp	2026-02-26 19:18:27
authored	[InstanceEdit:9976368] May, Bruce, 2025-12-11
compartment	[Compartment:7660] nucleoplasm [Compartment:984] extracellular region
created	[InstanceEdit:9976404] May, Bruce, 2025-12-11
edited	[InstanceEdit:9976368] May, Bruce, 2025-12-11
inferredFrom	[BlackBoxEvent:9978121] Gata3, Chd4, Ep300, Nfatc2, Yy1, Ets1, Pou2f1 (Oct1), Pou2f2 (Oct2), Batf, Satb1, Irf4, Smarca4, and Stat6 positively regulate expression of Il13 [Mus musculus]
input	[EntityWithAccessionedSequence:9976405] IL13 gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9978792] Matthews, Lisa, 2026-01-07
isChimeric	FALSE
literatureReference	[LiteratureReference:9977431] GATA3 siRNA inhibits the binding of NFAT1 to interleukin-13 promoter in human T cells
modified	[InstanceEdit:9976451] May, Bruce, 2025-12-11 [InstanceEdit:9977478] May, Bruce, 2025-12-20 [InstanceEdit:9977785] May, Bruce, 2025-12-23 [InstanceEdit:9978144] May, Bruce, 2025-12-27 [InstanceEdit:9979432] May, Bruce, 2026-01-19 [InstanceEdit:9979435] May, Bruce, 2026-01-19 [InstanceEdit:9983437] May, Bruce, 2026-02-24 [InstanceEdit:9983731] May, Bruce, 2026-02-26
name	GATA3, CHD4, EP300, NFATC2, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 positively regulate expression of IL13
output	[EntityWithAccessionedSequence:447211] IL13 [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:9976381] GATA3, CHD4, EP300, and NFATC2 bind the IL13 gene [Homo sapiens] [BlackBoxEvent:9976143] STAT6, NFATC2 (NFAT1), and NICD1,2 positively regulate expression of GATA3 [Homo sapiens] [BlackBoxEvent:2025882] Calcineurin dephosphorylates NFATC1,2,3 [Homo sapiens] [Reaction:9977764] GATA3, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 bind the Locus Control Region (LCR) in the RAD50 gene [Homo sapiens] [BlackBoxEvent:9976143] STAT6, NFATC2 (NFAT1), and NICD1,2 positively regulate expression of GATA3 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[PositiveGeneExpressionRegulation:9976384] Positive gene expression regulation by 'GATA3:CHD4:EP300:p-S243-NFATC2:IL13 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9977763] Positive gene expression regulation by 'GATA3:YY1:ETS1:POU2F1:POU2F2:BATF:p-Y641-STAT6:SATB1:IRF4:SMARCA4:RAD50 gene [nucleoplasm]'
releaseDate	2026-03-25
reviewed	[InstanceEdit:9983436] Barbutti, Isabella, 2026-02-24 [InstanceEdit:9983730] Lord, Graham M, 2026-02-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9976410] R-HSA-9976402.1
structureModified	[InstanceEdit:9977785] May, Bruce, 2025-12-23
summation	[Summation:9976376] GATA3, CHD4, and EP300 bind upstream of the IL13 gene. EP300...
(hasEvent)	[Pathway:9976102] Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) [Homo sapiens]
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No pathways have been reviewed or authored by GATA3, CHD4, EP300, NFATC2, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 positively regulate expression of IL13 (9976402)