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Details on Person GATA3 bound to 3 sites in the promoter of the IL5 gene regul...

Class:IdSummation:9976395
_displayNameGATA3 bound to 3 sites in the promoter of the IL5 gene regul...
_timestamp2025-12-20 17:51:33
created[InstanceEdit:9976404] May, Bruce, 2025-12-11
literatureReference[LiteratureReference:9976372] Characterization of cis-regulatory elements and nuclear factors conferring Th2-specific expression of the IL-5 gene: a role for a GATA-binding protein
[LiteratureReference:9976122] Genome-Wide Gene Expression Profiling Revealed a Critical Role for GATA3 in the Maintenance of the Th2 Cell Identity
[LiteratureReference:9977460] Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene
[LiteratureReference:9977463] Hierarchical IL-5 expression defines a subpopulation of highly differentiated human Th2 cells
modified[InstanceEdit:9977478] May, Bruce, 2025-12-20
textGATA3 bound to 3 sites in the promoter of the IL5 gene regulates transcription (Schwenger et al. 2001, and inferred from mouse homologs in Zhang et al. 1997, Lee et al. 1998, Sasaki et al. 2013). GATA3 at -70 bp and -152 bp positively regulate transcription; GATA3 at -400 bp negatively regulates transcription (Schwenger et al. 2013). Only about 20% of human Th2 cells produce IL5 and such cells appear to be more highly differentiated than Th2 cells that do not express IL5 (Upadhyaya et al. 2011).
(summation)[BlackBoxEvent:9976371] GATA3 regulates expression of IL5 [Homo sapiens]
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