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Details on Person GATA3 binds the IL5 gene

Class:Id	Reaction:9976390
_displayName	GATA3 binds the IL5 gene
_doRelease	TRUE
_timestamp	2026-02-26 19:18:09
authored	[InstanceEdit:9976368] May, Bruce, 2025-12-11
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9976404] May, Bruce, 2025-12-11
edited	[InstanceEdit:9976368] May, Bruce, 2025-12-11
inferredFrom	[Reaction:9978124] Gata3 binds the Il5 gene [Mus musculus]
input	[EntityWithAccessionedSequence:9976400] IL5 gene [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:996768] GATA3 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:996768] GATA3 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:996768] GATA3 [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9978792] Matthews, Lisa, 2026-01-07
isChimeric	FALSE
literatureReference	[LiteratureReference:9976401] GATA-3 has dual regulatory functions in human interleukin-5 transcription [LiteratureReference:9977452] SATB1 dictates expression of multiple genes including IL-5 involved in human T helper cell differentiation [LiteratureReference:9977463] Hierarchical IL-5 expression defines a subpopulation of highly differentiated human Th2 cells [LiteratureReference:9945893] T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements
modified	[InstanceEdit:9977478] May, Bruce, 2025-12-20 [InstanceEdit:9978144] May, Bruce, 2025-12-27 [InstanceEdit:9978164] May, Bruce, 2025-12-28 [InstanceEdit:9979435] May, Bruce, 2026-01-19 [InstanceEdit:9983437] May, Bruce, 2026-02-24 [InstanceEdit:9983731] May, Bruce, 2026-02-26
name	GATA3 binds the IL5 gene
output	[Complex:9976367] GATA3:IL5 gene [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9976143] STAT6, NFATC2 (NFAT1), and NICD1,2 positively regulate expression of GATA3 [Homo sapiens] [Reaction:9976117] STAT6, NFATC2 (NFAT1), and NICD1,2 bind the GATA3 gene and cause displacement of repressor complexes (PRC1, RBPJ:NCOR) by activator complexes (MLL1, RBPJ:NICD1,2) [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2026-03-25
reviewed	[InstanceEdit:9983436] Barbutti, Isabella, 2026-02-24 [InstanceEdit:9983730] Lord, Graham M, 2026-02-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9976414] R-HSA-9976390.1
structureModified	[InstanceEdit:9977478] May, Bruce, 2025-12-20
summation	[Summation:9976379] GATA3 binds 3 sites in the proximal 400 bp of the IL5 promot...
(hasEvent)	[Pathway:9976102] Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9976371] GATA3 regulates expression of IL5 [Homo sapiens]
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