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Details on Person GATA3, CHD4, EP300, and NFATC2 bind the IL13 gene

Class:Id	Reaction:9976381
_displayName	GATA3, CHD4, EP300, and NFATC2 bind the IL13 gene
_doRelease	TRUE
_timestamp	2026-02-26 19:18:32
authored	[InstanceEdit:9976368] May, Bruce, 2025-12-11
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9976404] May, Bruce, 2025-12-11
edited	[InstanceEdit:9976368] May, Bruce, 2025-12-11
inferredFrom	[Reaction:9978103] Gata3, Chd4, Ep300, and Nfatc2 bind the Il13 gene [Mus musculus]
input	[EntityWithAccessionedSequence:3702078] CHD4 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:381325] EP300 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:996768] GATA3 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9976405] IL13 gene [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:2025894] p-S243-NFATC2 [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9978792] Matthews, Lisa, 2026-01-07
isChimeric	FALSE
literatureReference	[LiteratureReference:9976136] Coordinated regulation of IL-4 and IL-13 expression in human T cells: 3C analysis for DNA looping [LiteratureReference:9977431] GATA3 siRNA inhibits the binding of NFAT1 to interleukin-13 promoter in human T cells [LiteratureReference:9945893] T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements
modified	[InstanceEdit:9976451] May, Bruce, 2025-12-11 [InstanceEdit:9977435] May, Bruce, 2025-12-19 [InstanceEdit:9978144] May, Bruce, 2025-12-27 [InstanceEdit:9978164] May, Bruce, 2025-12-28 [InstanceEdit:9979435] May, Bruce, 2026-01-19 [InstanceEdit:9983437] May, Bruce, 2026-02-24 [InstanceEdit:9983731] May, Bruce, 2026-02-26
name	GATA3, CHD4, EP300, and NFATC2 bind the IL13 gene
output	[Complex:9976378] GATA3:CHD4:EP300:p-S243-NFATC2:IL13 gene [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9976143] STAT6, NFATC2 (NFAT1), and NICD1,2 positively regulate expression of GATA3 [Homo sapiens] [Reaction:9976117] STAT6, NFATC2 (NFAT1), and NICD1,2 bind the GATA3 gene and cause displacement of repressor complexes (PRC1, RBPJ:NCOR) by activator complexes (MLL1, RBPJ:NICD1,2) [Homo sapiens] [BlackBoxEvent:2025882] Calcineurin dephosphorylates NFATC1,2,3 [Homo sapiens] [Reaction:2025890] Calcineurin binds NFATC1,2,3 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2026-03-25
reviewed	[InstanceEdit:9983436] Barbutti, Isabella, 2026-02-24 [InstanceEdit:9983730] Lord, Graham M, 2026-02-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9976408] R-HSA-9976381.1
structureModified	[InstanceEdit:9976451] May, Bruce, 2025-12-11
summation	[Summation:9976380] GATA3 and NFATC2 (NFAT1) bind upstream of the IL13 transcrip...
(hasEvent)	[Pathway:9976102] Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9976402] GATA3, CHD4, EP300, NFATC2, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 positively regulate expression of IL13 [Homo sapiens]
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No pathways have been reviewed or authored by GATA3, CHD4, EP300, and NFATC2 bind the IL13 gene (9976381)