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Details on Person OAT3 transports xenobiotics with antiport of dicarboxylate

Class:IdReaction:9975267
_displayNameOAT3 transports xenobiotics with antiport of dicarboxylate
_doReleaseFALSE
_timestamp2025-12-17 10:22:12
authored[InstanceEdit:9975257] Stephan, Ralf, 2025-11-29
catalystActivity[CatalystActivity:9975271] xenobiotic transmembrane transporter activity of SLC22A8 [plasma membrane]
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9975269] Stephan, Ralf, 2025-11-29
goBiologicalProcess[GO_BiologicalProcess:8935661] xenobiotic detoxification by transmembrane export across the plasma membrane
input[DefinedSet:9975270] SLC22A8 xenobiotics cargo [extracellular region]
[DefinedSet:9973008] 2OG / glutarate [cytosol]
internalReviewed[InstanceEdit:9977118] Matthews, Lisa, 2025-12-17
isChimericFALSE
literatureReference[LiteratureReference:9973751] The SLC22 Transporter Family: A Paradigm for the Impact of Drug Transporters on Metabolic Pathways, Signaling, and Disease
[LiteratureReference:9975016] Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology
[LiteratureReference:561045] Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux
[LiteratureReference:9974324] Inhibition of Methotrexate Uptake via Organic Anion Transporters OAT1 and OAT3 by Glucuronides of Nonsteroidal Anti-inflammatory Drugs
[LiteratureReference:9974337] Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor
[LiteratureReference:9974282] Inhibitory effect of JBP485 on renal excretion of acyclovir by the inhibition of OAT1 and OAT3
[LiteratureReference:9974335] Organic anion transporters involved in the excretion of bestatin in the kidney
[LiteratureReference:9974388] Renal secretion of hydrochlorothiazide involves organic anion transporter 1/3, organic cation transporter 2, and multidrug and toxin extrusion protein 2-K
[LiteratureReference:9974585] Human organic anion transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) transport edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and its sulfate conjugate
[LiteratureReference:9975368] Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1
[LiteratureReference:9974323] In vitro and in vivo assessment of renal drug transporters in the disposition of mesna and dimesna
[LiteratureReference:9974276] Interactions of human organic anion transporters with diuretics
[LiteratureReference:9974345] A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters
[LiteratureReference:9975255] Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney
[LiteratureReference:9975359] Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A)
[LiteratureReference:9974320] Probenecid, an organic anion transporter 1 and 3 inhibitor, increases plasma and brain exposure of N-acetylcysteine
[LiteratureReference:9975376] Completing the Enalaprilat Excretion Pathway-Renal Handling by the Proximal Tubule
[LiteratureReference:9974861] Counter-flow suggests transport of dantrolene and 5-OH dantrolene by the organic anion transporters 2 (OAT2) and 3 (OAT3)
[LiteratureReference:9975386] Role of organic anion transporter 3 in the renal excretion of biapenem and potential drug-drug interactions
[LiteratureReference:9975369] Role of transporters in the disposition of a novel β-lactamase inhibitor: relebactam (MK-7655)
[LiteratureReference:9975366] Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid
[LiteratureReference:9975356] Renal organic anion transporter-mediated drug-drug interaction between gemcabene and quinapril
[LiteratureReference:9975404] Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein
[LiteratureReference:9975397] The contribution of organic anion transporters OAT1 and OAT3 to the renal uptake of rosuvastatin
[LiteratureReference:9974318] In vitro and in silico characterization of the transport of selected perfluoroalkyl carboxylic acids and perfluoroalkyl sulfonic acids by human organic anion transporter 1 (OAT1), OAT2 and OAT3
[LiteratureReference:9974319] Evaluation of 14 PFAS for permeability and organic anion transporter interactions: Implications for renal clearance in humans
[LiteratureReference:9974347] Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8)
[LiteratureReference:9974341] Stereoselective inhibitory effect of flurbiprofen, ibuprofen and naproxen on human organic anion transporters hOAT1 and hOAT3
[LiteratureReference:9975398] Characteristics of pemetrexed transport by renal basolateral organic anion transporter hOAT3
[LiteratureReference:9974299] Critical role of organic anion transporters 1 and 3 in kidney accumulation and toxicity of aristolochic acid I
[LiteratureReference:9973752] Characterization of uremic toxin transport by organic anion transporters in the kidney
[LiteratureReference:9970022] Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes
[LiteratureReference:9971569] Gut-derived uremic toxin handling in vivo requires OAT-mediated tubular secretion in chronic kidney disease
modified[InstanceEdit:9975379] Stephan, Ralf, 2025-12-01
[InstanceEdit:9975396] Stephan, Ralf, 2025-12-01
[InstanceEdit:9977119] Stephan, Ralf, 2025-12-17
nameOAT3 transports xenobiotics with antiport of dicarboxylate
output[DefinedSet:9975268] SLC22A8 xenobiotics cargo [cytosol]
[DefinedSet:9973016] 2OG / glutarate [extracellular region]
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9975274] R-HSA-9975267.1
summation[Summation:9975409] Solute carrier family 22 member 8 (SLC22A8; aka Organic anio...
(hasEvent)[Pathway:561048] Organic anion transport by SLC22 transporters [Homo sapiens]
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No pathways have been reviewed or authored by OAT3 transports xenobiotics with antiport of dicarboxylate (9975267)
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