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Details on Person Solute carrier family 22 member 8 (SLC22A8; aka Organic anio...
| Class:Id | Summation:9975262 |
|---|---|
| _displayName | Solute carrier family 22 member 8 (SLC22A8; aka Organic anio... |
| _timestamp | 2025-12-17 09:53:23 |
| created | [InstanceEdit:9975257] Stephan, Ralf, 2025-11-29 |
| modified | [InstanceEdit:9977117] Stephan, Ralf, 2025-12-17 |
| text | Solute carrier family 22 member 8 (SLC22A8; aka Organic anion transporter 3, OAT3) imports a molecule of endogenous metabolites at the basolateral membrane of renal proximal tubule cells from the blood stream (reviewed in VanWert et al., 2010; Nigam, 2018). Simultaneously, one molecule of 2-oxoglutarate (2OG) or glutarate (see e.g. Bakhya et al., 2003) is antiported. The most important metabolites transported are urate (Bakhya et al., 2003), prostaglandins PGE2 and PGF2alpha (Kimura et al., 2002), biopterins BH2, BH4, and sepiapterin (Ohashi et al., 2017), cAMP and taurocholate (Cha et al., 2001), taurine (Tsuruya et al., 2016), N-benzoylglycine aka hippurate (HIPA) (Deguchi et al., 2004), xanthurenate (Uwai & Honjo, 2013), kynurenate (Uwai et al., 2012), citrulline and 1-methyl-imidazoleacetate (Wu et al., 2017), hypotaurine, putrescine, 5-methylthioadenosine, picolinate, N-acetylkynurenine, 3-(4-hydroxyphenyl)lactate, glucuronate, sebacate, cholate, 7-methylguanine and cytidine (Bush et al., 2020). SLC22A8 is also localized on the apical (ventricular/cerebrospinal-fluid (CSF)--facing) membrane of choroid plexus epithelial cells which form the blood-CSF barrier. There it acts to actively clear potentially harmful organic anions from the CSF (reviewed e.g. in Nigam, 2018). |
| (summation) | [Reaction:9974998] OAT3 transports endogenous metabolites with antiport of dicarboxylate [Homo sapiens] |
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No pathways have been reviewed or authored by Solute carrier family 22 member 8 (SLC22A8; aka Organic anio... (9975262)
