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Details on Person NSP1 promotes 26S proteasome-dependent degradation of IRF5, IRF7

Class:Id	BlackBoxEvent:9974947
_displayName	NSP1 promotes 26S proteasome-dependent degradation of IRF5, IRF7
_doRelease	FALSE
_timestamp	2026-01-21 22:27:22
authored	[InstanceEdit:9979788] Orlic-Milacic, Marija, 2026-01-21
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9974934] Orlic-Milacic, Marija, 2025-11-27
disease	[Disease:3134794] viral infectious disease
input	[DefinedSet:9974958] PolyUb-IRF5, PolyUb-IRF7 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9974897] Diversity of interferon antagonist activities mediated by NSP1 proteins of different rotavirus strains [LiteratureReference:9974883] NSP1 of human rotaviruses commonly inhibits NF-κB signalling by inducing β-TrCP degradation
modified	[InstanceEdit:9979789] Orlic-Milacic, Marija, 2026-01-21 [InstanceEdit:9979821] Orlic-Milacic, Marija, 2026-01-21
name	NSP1 promotes 26S proteasome-dependent degradation of IRF5, IRF7
output	[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9974206] NSP1 binds the Cul3-RING ligase (CRL3) complex [Homo sapiens] [Reaction:9821577] CK2 phosphorylates NSP1 [Homo sapiens]
regulatedBy	[PositiveRegulation:9974936] Positive regulation by 'RBX1:CUL3:p-S-480,483-NSP1 [cytosol]'
relatedSpecies	[Species:9615053] Rotavirus A
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9974969] R-HSA-9974947.1
summation	[Summation:9974944] NSP1 proteins from some human RV-A strains, namely Wa, K8...
(hasEvent)	[Pathway:9974192] Rotavirus A (RV-A) host interactions [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9979809] Futile Cycle: NSP1 promotes 26S proteasome-dependent degradation of IRF5, IRF7 [NegativePrecedingEvent:9979818] Futile Cycle: NSP1 promotes 26S proteasome-dependent degradation of IRF5, IRF7
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No pathways have been reviewed or authored by NSP1 promotes 26S proteasome-dependent degradation of IRF5, IRF7 (9974947)