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Details on Person CRL3-NSP1 complex binds BTRC

Class:Id	Reaction:9974798
_displayName	CRL3-NSP1 complex binds BTRC
_doRelease	FALSE
_timestamp	2026-01-21 15:42:13
authored	[InstanceEdit:9979788] Orlic-Milacic, Marija, 2026-01-21
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9974796] Orlic-Milacic, Marija, 2025-11-26
disease	[Disease:3134794] viral infectious disease
input	[Complex:9974751] RBX1:CUL3:p-S-480,483-NSP1 [cytosol] [Homo sapiens] [Complex:206748] BTRC:CUL1:RBX1:SKP1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9974744] Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex
modified	[InstanceEdit:9974814] Orlic-Milacic, Marija, 2025-11-26 [InstanceEdit:9979789] Orlic-Milacic, Marija, 2026-01-21
name	CRL3-NSP1 complex binds BTRC
output	[Complex:9974793] CRL3-NSP1:SCF-BTRC [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9974206] NSP1 binds the Cul3-RING ligase (CRL3) complex [Homo sapiens] [Reaction:9821577] CK2 phosphorylates NSP1 [Homo sapiens]
relatedSpecies	[Species:9615053] Rotavirus A
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9974804] R-HSA-9974798.1
summation	[Summation:9974810] NSP1 of human rotavirus A (RV-A) strains Wa and ST3 function...
(hasEvent)	[Pathway:9974192] Rotavirus A (RV-A) host interactions [Homo sapiens]
(precedingEvent)	[Reaction:9974789] CRL3-NSP1 complex polyubiquitinates BTRC [Homo sapiens]
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No pathways have been reviewed or authored by CRL3-NSP1 complex binds BTRC (9974798)