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Details on Person 20S proteasome-mediated degradation of PolyUb-BTRC and NSP1

Class:Id	BlackBoxEvent:9974797
_displayName	20S proteasome-mediated degradation of PolyUb-BTRC and NSP1
_timestamp	2026-01-21 15:42:00
authored	[InstanceEdit:9979788] Orlic-Milacic, Marija, 2026-01-21
catalystActivity	[CatalystActivity:9912733] endopeptidase activity of PA28-alpha-beta-20S proteasome [cytosol]
created	[InstanceEdit:9974796] Orlic-Milacic, Marija, 2025-11-26
disease	[Disease:3134794] viral infectious disease
input	[Complex:9974799] CRL3-NSP1:SCF-PolyUb-BTRC [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9974744] Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex [LiteratureReference:9974890] Rotavirus NSP1 Associates with Components of the Cullin RING Ligase Family of E3 Ubiquitin Ligases [LiteratureReference:9974897] Diversity of interferon antagonist activities mediated by NSP1 proteins of different rotavirus strains
modified	[InstanceEdit:9974814] Orlic-Milacic, Marija, 2025-11-26 [InstanceEdit:9974899] Orlic-Milacic, Marija, 2025-11-26 [InstanceEdit:9974900] Orlic-Milacic, Marija, 2025-11-26 [InstanceEdit:9979789] Orlic-Milacic, Marija, 2026-01-21
name	20S proteasome-mediated degradation of PolyUb-BTRC and NSP1
output	[EntityWithAccessionedSequence:174230] CUL1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:180582] RBX1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:174150] SKP1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:975979] CUL3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:180582] RBX1 [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9974789] CRL3-NSP1 complex polyubiquitinates BTRC [Homo sapiens] [Reaction:9974798] CRL3-NSP1 complex binds BTRC [Homo sapiens]
relatedSpecies	[Species:9615053] Rotavirus A
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9974806] R-HSA-9974797.1
summation	[Summation:9974813] Polyubiquitination of BTRC (beta-TrCP), the substrate recogn...
(hasEvent)	[Pathway:9974192] Rotavirus A (RV-A) host interactions [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9979807] Futile Cycle: 20S proteasome-mediated degradation of PolyUb-BTRC and NSP1 [NegativePrecedingEvent:9979812] Futile Cycle: 20S proteasome-mediated degradation of PolyUb-BTRC and NSP1 [NegativePrecedingEvent:9979819] Futile Cycle: 20S proteasome-mediated degradation of PolyUb-BTRC and NSP1
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