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Details on Person Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex

Class:IdLiteratureReference:9974744
_displayNameComparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex
_timestamp2025-11-25 04:33:39
author[Person:9772365] Ding, Siyuan
[Person:9974746] Mooney, Nancie
[Person:9822447] Li, Bin
[Person:9974750] Kelly, Marcus R
[Person:9974195] Feng, Ningguo
[Person:5617503] Loktev, Alexander V
[Person:9973643] Sen, Adrish
[Person:9614533] Patton, John T
[Person:5609712] Jackson, Peter K
[Person:9772373] Greenberg, Harry B
created[InstanceEdit:9974749] Orlic-Milacic, Marija, 2025-11-25
journalPLoS Pathog
pagese1005929
pubMedIdentifier27706223
titleComparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex
volume12
year2016
(literatureReference)[Complex:9974751] RBX1:CUL3:p-S-480,483-NSP1 [cytosol] [Homo sapiens]
[Complex:9974937] RBX1:CUL3:p-S-480,483-NSP1 (WI61) [cytosol] [Homo sapiens]
[Reaction:9974206] NSP1 binds the Cul3-RING ligase (CRL3) complex [Homo sapiens]
[Reaction:9974789] CRL3-NSP1 complex polyubiquitinates BTRC [Homo sapiens]
[BlackBoxEvent:9974797] 20S proteasome-mediated degradation of PolyUb-BTRC and NSP1 [Homo sapiens]
[Reaction:9974798] CRL3-NSP1 complex binds BTRC [Homo sapiens]
[Reaction:9974817] SCF-Beta-TrCP complex binding to NFKB p50:p65:phospho-IKBA complex is negatively regulated by RV-A NSP1 [Homo sapiens]
[Summation:9974739]

NSP1 nonstructural protein of various rotavirus A (RV-A) ...
[Summation:9974810] NSP1 of human rotavirus A (RV-A) strains Wa and ST3 function...
[Summation:9974811] NSP1, serving as the substrate-recognition subunit of the CU...

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