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Details on Person NSP1 binds the Cul3-RING ligase (CRL3) complex

Class:Id	Reaction:9974206
_displayName	NSP1 binds the Cul3-RING ligase (CRL3) complex
_doRelease	FALSE
_timestamp	2026-01-21 22:27:19
authored	[InstanceEdit:9979788] Orlic-Milacic, Marija, 2026-01-21
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9974205] Orlic-Milacic, Marija, 2025-11-20
disease	[Disease:3134794] viral infectious disease
input	[EntityWithAccessionedSequence:180582] RBX1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:975979] CUL3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9821574] p-S480,S483-NSP1 [cytosol] [Rotavirus A]
isChimeric	FALSE
literatureReference	[LiteratureReference:9974744] Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex [LiteratureReference:9821597] Rotavirus NSP1 Requires Casein Kinase II-Mediated Phosphorylation for Hijacking of Cullin-RING Ligases [LiteratureReference:9974890] Rotavirus NSP1 Associates with Components of the Cullin RING Ligase Family of E3 Ubiquitin Ligases
modified	[InstanceEdit:9974727] Orlic-Milacic, Marija, 2025-11-24 [InstanceEdit:9974743] Orlic-Milacic, Marija, 2025-11-24 [InstanceEdit:9974753] Orlic-Milacic, Marija, 2025-11-25 [InstanceEdit:9974787] Orlic-Milacic, Marija, 2025-11-25 [InstanceEdit:9974788] Orlic-Milacic, Marija, 2025-11-25 [InstanceEdit:9974792] Orlic-Milacic, Marija, 2025-11-25 [InstanceEdit:9974808] Orlic-Milacic, Marija, 2025-11-26 [InstanceEdit:9974896] Orlic-Milacic, Marija, 2025-11-26 [InstanceEdit:9979789] Orlic-Milacic, Marija, 2026-01-21 [InstanceEdit:9979821] Orlic-Milacic, Marija, 2026-01-21
name	NSP1 binds the Cul3-RING ligase (CRL3) complex
negativePrecedingEvent	[NegativePrecedingEvent:9979819] Futile Cycle: 20S proteasome-mediated degradation of PolyUb-BTRC and NSP1
output	[Complex:9974751] RBX1:CUL3:p-S-480,483-NSP1 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9821577] CK2 phosphorylates NSP1 [Homo sapiens] [BlackBoxEvent:9965297] Translation of RV-A NSP1 [Homo sapiens]
relatedSpecies	[Species:9615053] Rotavirus A
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9974208] R-HSA-9974206.1
structureModified	[InstanceEdit:9974753] Orlic-Milacic, Marija, 2025-11-25
summation	[Summation:9974739] NSP1 nonstructural protein of various rotavirus A (RV-A) ...
(hasEvent)	[Pathway:9974192] Rotavirus A (RV-A) host interactions [Homo sapiens]
(precedingEvent)	[Reaction:9974798] CRL3-NSP1 complex binds BTRC [Homo sapiens] [BlackBoxEvent:9974947] NSP1 promotes 26S proteasome-dependent degradation of IRF5, IRF7 [Homo sapiens]
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