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Details on Person Transcription of polycistronic ORF73-ORF72-ORF71 pre-mRNA

Class:Id	BlackBoxEvent:9973887
_displayName	Transcription of polycistronic ORF73-ORF72-ORF71 pre-mRNA
_doRelease	FALSE
_timestamp	2026-02-24 14:44:57
created	[InstanceEdit:9973888] Orlic-Milacic, Marija, 2025-11-18
disease	[Disease:3134794] viral infectious disease
input	[EntityWithAccessionedSequence:9980742] ORF73-ORF72-ORF71 gene [nucleoplasm] [Human herpesvirus 8]
isChimeric	FALSE
literatureReference	[LiteratureReference:9980820] Transcriptional analysis of human herpesvirus-8 open reading frames 71, 72, 73, K14, and 74 in a primary effusion lymphoma cell line [LiteratureReference:9980819] A cluster of latently expressed genes in Kaposi's sarcoma-associated herpesvirus [LiteratureReference:9980843] Piracy of prostaglandin E2/EP receptor-mediated signaling by Kaposi's sarcoma-associated herpes virus (HHV-8) for latency gene expression: strategy of a successful pathogen [LiteratureReference:9980877] Characterization and cell cycle regulation of the major Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) latent genes and their promoter
modified	[InstanceEdit:9980756] Orlic-Milacic, Marija, 2026-02-02 [InstanceEdit:9980768] Orlic-Milacic, Marija, 2026-02-02 [InstanceEdit:9980818] Orlic-Milacic, Marija, 2026-02-03 [InstanceEdit:9980838] Orlic-Milacic, Marija, 2026-02-03 [InstanceEdit:9980849] Orlic-Milacic, Marija, 2026-02-03 [InstanceEdit:9980878] Orlic-Milacic, Marija, 2026-02-03 [InstanceEdit:9983303] Stephan, Ralf, 2026-02-21 [InstanceEdit:9983420] Orlic-Milacic, Marija, 2026-02-24
name	Transcription of polycistronic ORF73-ORF72-ORF71 pre-mRNA
output	[EntityWithAccessionedSequence:9980751] ORF73-ORF72-ORF71 polycistronic mRNA [nucleoplasm] [Human herpesvirus 8]
precedingEvent	[Reaction:9980757] LANA1 binds LANA promoter [Homo sapiens] [BlackBoxEvent:9978628] PRMT1 methylates Arg-20 in LANA1 dimer [Homo sapiens] [BlackBoxEvent:9980737] NOTCH2 coactivator complex binds LANA promoter [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9980761] Positive gene expression regulation by 'Me-R20-p-S10,T14-LANA1 oligomer:LANA promoter [nucleoplasm]' [PositiveGeneExpressionRegulation:9980810] Positive gene expression regulation by 'NOTCH2 Coactivator Complex:LANA promoter [nucleoplasm]' [PositiveRegulation:9980847] Positive regulation by 'PGE2 [extracellular region]'
relatedSpecies	[Species:2671781] Human herpesvirus 8
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9973901] R-HSA-9973887.1
structureModified	[InstanceEdit:9980756] Orlic-Milacic, Marija, 2026-02-02 [InstanceEdit:9980768] Orlic-Milacic, Marija, 2026-02-02 [InstanceEdit:9980818] Orlic-Milacic, Marija, 2026-02-03 [InstanceEdit:9980849] Orlic-Milacic, Marija, 2026-02-03
summation	[Summation:9980832] Three HHV8 (KSHV) genes are transcribed from the LANA promot...
(hasEvent)	[Pathway:9973880] Transcription of HHV8 latency locus genes [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9973890] ORF71 protein synthesis [Homo sapiens] [BlackBoxEvent:9973891] ORF72 protein synthesis [Homo sapiens] [BlackBoxEvent:9980753] ORF73 protein synthesis [Homo sapiens]
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No pathways have been reviewed or authored by Transcription of polycistronic ORF73-ORF72-ORF71 pre-mRNA (9973887)