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Details on Person LANA1 tethers HHV8 circular dsDNA to host chromosomes

Class:Id	Reaction:9973876
_displayName	LANA1 tethers HHV8 circular dsDNA to host chromosomes
_doRelease	FALSE
_timestamp	2026-02-24 14:44:40
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9973874] Orlic-Milacic, Marija, 2025-11-18
disease	[Disease:3134794] viral infectious disease
goBiologicalProcess	[GO_BiologicalProcess:2454637] establishment of latency as a circular episome
input	[Complex:9982061] Condensed prophase chromosome [nucleoplasm] [Homo sapiens] [Complex:9983417] HHV8 Circular Episome:Me-R20-p-S10,T14-LANA1 oligomer [nucleoplasm] [Human herpesvirus 8]
isChimeric	FALSE
literatureReference	[LiteratureReference:9981979] Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mediates episome persistence through cis-acting terminal repeat (TR) sequence and specifically binds TR DNA [LiteratureReference:9981983] Chromosome binding site of latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus is essential for persistent episome maintenance and is functionally replaced by histone H1 [LiteratureReference:9978542] KSHV LANA1 binds DNA as an oligomer and residues N-terminal to the oligomerization domain are essential for DNA binding, replication, and episome persistence [LiteratureReference:9982003] Visualization of a functional KSHV episome-maintenance protein LANA in living cells [LiteratureReference:9981999] Disruption of Kaposi's sarcoma-associated herpesvirus latent nuclear antigen leads to abortive episome persistence [LiteratureReference:9982011] Analysis of viral cis elements conferring Kaposi's sarcoma-associated herpesvirus episome partitioning and maintenance [LiteratureReference:9982012] The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA [LiteratureReference:9982016] Role of Kaposi's sarcoma-associated herpesvirus C-terminal LANA chromosome binding in episome persistence [LiteratureReference:9980856] Molecular basis for oligomeric-DNA binding and episome maintenance by KSHV LANA [LiteratureReference:9983390] LANA-Mediated Recruitment of Host Polycomb Repressive Complexes onto the KSHV Genome during De Novo Infection [LiteratureReference:9983397] Site-specific association with host and viral chromatin by Kaposi's sarcoma-associated herpesvirus LANA and its reversal during lytic reactivation [LiteratureReference:9983304] Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen: Replicating and Shielding Viral DNA during Viral Persistence
modified	[InstanceEdit:9973930] Orlic-Milacic, Marija, 2025-11-18 [InstanceEdit:9978665] Stephan, Ralf, 2026-01-04 [InstanceEdit:9981993] Orlic-Milacic, Marija, 2026-02-12 [InstanceEdit:9982008] Orlic-Milacic, Marija, 2026-02-12 [InstanceEdit:9982019] Orlic-Milacic, Marija, 2026-02-12 [InstanceEdit:9982097] Orlic-Milacic, Marija, 2026-02-13 [InstanceEdit:9982886] Stephan, Ralf, 2026-02-20 [InstanceEdit:9983303] Stephan, Ralf, 2026-02-21 [InstanceEdit:9983392] Stephan, Ralf, 2026-02-23 [InstanceEdit:9983419] Orlic-Milacic, Marija, 2026-02-24 [InstanceEdit:9983420] Orlic-Milacic, Marija, 2026-02-24
name	LANA1 tethers HHV8 circular dsDNA to host chromosomes
output	[Complex:9981981] Me-R20-LANA1 Oligomer:HHV8 Circular Episome:Condensed prophase chromosome [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9973875] HHV8 dsDNA circularizes into an episome [Homo sapiens] [BlackBoxEvent:9973861] HHV8 dsDNA enters the host cell nucleus [Homo sapiens] [Reaction:9980758] LANA1 oligomerizes on episome [Homo sapiens] [BlackBoxEvent:9980753] ORF73 protein synthesis [Homo sapiens] [BlackBoxEvent:9973875] HHV8 dsDNA circularizes into an episome [Homo sapiens] [BlackBoxEvent:9978628] PRMT1 methylates Arg-20 in LANA1 dimer [Homo sapiens]
relatedSpecies	[Species:2671781] Human herpesvirus 8
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9973878] R-HSA-9973876.1
structureModified	[InstanceEdit:9978665] Stephan, Ralf, 2026-01-04 [InstanceEdit:9981993] Orlic-Milacic, Marija, 2026-02-12 [InstanceEdit:9982097] Orlic-Milacic, Marija, 2026-02-13 [InstanceEdit:9983419] Orlic-Milacic, Marija, 2026-02-24
summation	[Summation:9981990] LANA1 binds to terminal repeats (TRs) of the circular episom...
(hasEvent)	[Pathway:9983305] Establishment of Latent HHV8 Infection [Homo sapiens]
(precedingEvent)	[Reaction:9983406] SIRT1 binds to ORF50 promoter [Homo sapiens] [Reaction:9983687] LANA1 recruits the SET1A complex [Homo sapiens] [Reaction:9983755] LANA1 recruits the PRC2 complex [Homo sapiens]
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No pathways have been reviewed or authored by LANA1 tethers HHV8 circular dsDNA to host chromosomes (9973876)