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Details on Person HHV8 dsDNA circularizes into an episome

Class:Id	BlackBoxEvent:9973875
_displayName	HHV8 dsDNA circularizes into an episome
_doRelease	FALSE
_timestamp	2026-02-21 10:19:19
catalystActivity	[CatalystActivity:9979940] DNA ligase activity of NHEJ, SSA, MMEJ DNA repair ligases [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9973874] Orlic-Milacic, Marija, 2025-11-18
disease	[Disease:3134794] viral infectious disease
input	[EntityWithAccessionedSequence:9979926] HHV8 Linear DNA [nucleoplasm] [Human herpesvirus 8]
isChimeric	FALSE
literatureReference	[LiteratureReference:9979917] The Kaposi sarcoma-associated herpesvirus (KSHV) is present as an intact latent genome in KS tissue but replicates in the peripheral blood mononuclear cells of KS patients [LiteratureReference:9979913] Kaposi's sarcoma herpesvirus exploits the DNA damage response to circularize its genome
modified	[InstanceEdit:9979935] Orlic-Milacic, Marija, 2026-01-23 [InstanceEdit:9979949] Orlic-Milacic, Marija, 2026-01-23 [InstanceEdit:9980195] Orlic-Milacic, Marija, 2026-01-26 [InstanceEdit:9983303] Stephan, Ralf, 2026-02-21
name	HHV8 dsDNA circularizes into an episome
output	[EntityWithAccessionedSequence:9979916] HHV8 Circular Episome [nucleoplasm] [Human herpesvirus 8]
precedingEvent	[BlackBoxEvent:9973861] HHV8 dsDNA enters the host cell nucleus [Homo sapiens] [BlackBoxEvent:9973862] Endocytosed HHV8 uncoats [Homo sapiens] [BlackBoxEvent:9987618] Capsid localizes to nuclear pore [Homo sapiens]
regulatedBy	[PositiveRegulation:9980183] Positive regulation by 'p-S1981,Ac-K3016-ATM [nucleoplasm]'
relatedSpecies	[Species:2671781] Human herpesvirus 8
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9973877] R-HSA-9973875.1
structureModified	[InstanceEdit:9979935] Orlic-Milacic, Marija, 2026-01-23 [InstanceEdit:9979949] Orlic-Milacic, Marija, 2026-01-23 [InstanceEdit:9980195] Orlic-Milacic, Marija, 2026-01-26
summation	[Summation:9979909] During latent infection, HHV8 (KHSV) linear DNA molecules fo...
(hasEvent)	[Pathway:9988179] Pre-Latent Lytic Burst [Homo sapiens]
(precedingEvent)	[Reaction:9973876] LANA1 tethers HHV8 circular dsDNA to host chromosomes [Homo sapiens] [Reaction:9980758] LANA1 oligomerizes on episome [Homo sapiens] [Reaction:9982105] ORF50 binds the circular episome [Homo sapiens]
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No pathways have been reviewed or authored by HHV8 dsDNA circularizes into an episome (9973875)