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Details on Person HHV8 is endocytosed into host cells

Class:Id	BlackBoxEvent:9973860
_displayName	HHV8 is endocytosed into host cells
_doRelease	FALSE
_timestamp	2026-04-19 17:57:15
authored	[InstanceEdit:9987545] Stephan, Ralf, 2026-04-18
created	[InstanceEdit:9973858] Orlic-Milacic, Marija, 2025-11-18
disease	[Disease:3134794] viral infectious disease
input	[DefinedSet:9987562] HHV8 virion:Receptors [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9987462] KSHV Entry and Trafficking in Target Cells-Hijacking of Cell Signal Pathways, Actin and Membrane Dynamics [LiteratureReference:9987587] ESCRT-I Protein Tsg101 Plays a Role in the Post-macropinocytic Trafficking and Infection of Endothelial Cells by Kaposi's Sarcoma-Associated Herpesvirus [LiteratureReference:9987584] c-Cbl-mediated selective virus-receptor translocations into lipid rafts regulate productive Kaposi's sarcoma-associated herpesvirus infection in endothelial cells [LiteratureReference:9987580] CIB1 synergizes with EphrinA2 to regulate Kaposi's sarcoma-associated herpesvirus macropinocytic entry in human microvascular dermal endothelial cells
modified	[InstanceEdit:9983303] Stephan, Ralf, 2026-02-21 [InstanceEdit:9987487] Stephan, Ralf, 2026-04-18 [InstanceEdit:9987559] Stephan, Ralf, 2026-04-19 [InstanceEdit:9987585] Stephan, Ralf, 2026-04-19
name	HHV8 is endocytosed into host cells
output	[DefinedSet:9987553] HHV8 virion:Receptors [early endosome membrane] [Homo sapiens]
precedingEvent	[Reaction:9987502] HHV8 gB and gH:gL bind integrins and EPHA2 [Homo sapiens] [Reaction:9987508] HHV8 gB binds integrins on fibroblasts and monocytes [Homo sapiens] [Reaction:9987526] HHV8 gB binds DC-SIGN on macrophages, dendritic cells and B cells [Homo sapiens]
relatedSpecies	[Species:2671781] Human herpesvirus 8
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9973867] R-HSA-9973860.1
summation	[Summation:9987582] HHV8 envelope glycoprotein interactions with host receptors ...
(hasEvent)	[Pathway:9973857] HHV8 Entry into Host Cells [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9973862] Endocytosed HHV8 uncoats [Homo sapiens]
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No pathways have been reviewed or authored by HHV8 is endocytosed into host cells (9973860)