Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
| Class:Id | ReferenceGeneProduct:99738 |
|---|---|
| _chainChangeLog | chain:1-122 added on Fri February 6 2015 |
| _displayName | UniProt:Q9NHX0 Roc1b |
| _timestamp | 2023-11-03 15:39:37 |
| chain | chain:1-122 |
| checksum | F22CE00438725410 |
| comment | FUNCTION Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity).PATHWAY Protein modification; protein ubiquitination.SUBUNIT Part of a SCF complex consisting of Skpa (SKP1), Cul1, Roc1B and a F-box protein.SUBCELLULAR LOCATION Highly expressed in early embryos, and in pupae. Widely expressed in adult males, while it is weakly expressed in adult females.DOMAIN The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion (By similarity).SIMILARITY Belongs to the RING-box family.CAUTION It is uncertain whether Met-1 or Met-16 is the initiator. |
| description | recommendedName: RING-box protein 1B alternativeName: Regulator of cullins 1b |
| geneName | Roc1b ROC2 CG16988 |
| identifier | Q9NHX0 |
| isSequenceChanged | FALSE |
| keyword | Cytoplasm Metal-binding Nucleus Reference proteome Ubl conjugation pathway Zinc Zinc-finger |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Roc1b |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | RBX1B_DROME Q9W0R1 |
| sequenceLength | 122 |
| species | [Species:56210] Drosophila melanogaster |
| (referenceEntity) | [EntityWithAccessionedSequence:216255] ROC1B [nucleoplasm] [Drosophila melanogaster] |
| [Change default viewing format] | |