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Details on Person UniProt:F5HGJ3 vBCL2
| Class:Id | ReferenceGeneProduct:9973394 |
|---|---|
| _chainChangeLog | chain:1-175 for 9973394 added on Fri Feb 20 2026 |
| _displayName | UniProt:F5HGJ3 vBCL2 |
| _timestamp | 2026-02-20 21:46:52 |
| chain | chain:1-175 |
| checksum | 5A13A3DB1902C306 |
| comment | FUNCTION Plays a role in the protection against apoptosis mediated by cytotoxic cells during the immune response to acute and persistent viral infection. Contributes therefore to latency establishment. Also plays a role in the inhibition of host starvation-induced autophagy which ultimately contributes to the viral chronic infection. Also participates in the viral genome replication within host nucleus (PubMed:28053098).SUBUNIT Interacts with human NOP53; may sequester ORF16 in host nucleolus and reduce its antiapoptotic activity. Interacts with ORF55.SUBCELLULAR LOCATION Belongs to the Bcl-2 family. |
| created | [InstanceEdit:9973335] Orlic-Milacic, Marija, 2025-11-14 |
| description | recommendedName: Apoptosis regulator Bcl-2 homolog |
| geneName | vBCL2 ORF16 |
| identifier | F5HGJ3 |
| isSequenceChanged | FALSE |
| keyword | Host membrane Host mitochondrion Host nucleus Host-virus interaction Inhibition of host apoptosis by viral BCL2-like protein Membrane Modulation of host cell apoptosis by virus Reference proteome Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | vBCL2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | ARBH_HHV8P |
| sequenceLength | 175 |
| species | [Species:2671781] Human herpesvirus 8 |
| (referenceEntity) | [EntityWithAccessionedSequence:9973293] vBCL2 [nucleolus] [Human herpesvirus 8] [EntityWithAccessionedSequence:9973308] vBCL2 [mitochondrial outer membrane] [Human herpesvirus 8] [EntityWithAccessionedSequence:9977539] vBCL2 [endoplasmic reticulum membrane] [Human herpesvirus 8] [EntityWithAccessionedSequence:9980118] vBCL2 [nucleoplasm] [Human herpesvirus 8] |
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No pathways have been reviewed or authored by UniProt:F5HGJ3 vBCL2 (9973394)
