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Details on Person UniProt:Q98146 ORF74
| Class:Id | ReferenceGeneProduct:9973379 |
|---|---|
| _chainChangeLog | chain:1-342 for 9973379 added on Fri Feb 20 2026 |
| _displayName | UniProt:Q98146 ORF74 |
| _timestamp | 2026-02-20 23:01:46 |
| chain | chain:1-342 |
| checksum | 41E4B33CA2D9F069 |
| comment | FUNCTION Receptor that signals constitutively via several signaling pathways including PI3K/AKT as well as mitogen- and stress-activated/MAP kinases. Promotes host cell proliferation and survival, modulates cell migration, stimulates angiogenesis, and recruits inflammatory cells, both in expressing cells and in neighboring cells. Maintains chronic activation of NF-kappa-B via interaction with host CADM1 (PubMed:29698475).SUBUNIT Interacts with protein K7; this interaction promotes vGPCR proteasomal degradation (PubMed:18802460). Interacts with host CADM1; this interaction is essential for chronic NF-kappa-B activation (PubMed:29698475).INTERACTION Belongs to the G-protein coupled receptor 1 family. |
| created | [InstanceEdit:9973335] Orlic-Milacic, Marija, 2025-11-14 |
| description | recommendedName: viral G-protein coupled receptor shortName: vGPCR alternativeName: Protein ORF74 |
| geneName | ORF74 |
| identifier | Q98146 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure G-protein coupled receptor Glycoprotein Host cell membrane Host membrane Membrane Receptor Reference proteome Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | ORF74 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | VGPCR_HHV8P O12573 P88966 Q77Q35 |
| sequenceLength | 342 |
| species | [Species:2671781] Human herpesvirus 8 |
| (referenceEntity) | [EntityWithAccessionedSequence:9973203] S-GlcNAc-N18,N22,N31,N202-ORF74 [plasma membrane] [Human herpesvirus 8] [EntityWithAccessionedSequence:9980406] ORF74 [endoplasmic reticulum membrane] [Human herpesvirus 8] [EntityWithAccessionedSequence:9980408] GlcNAc-N18,N22,N31,N202-ORF74 [Golgi membrane] [Human herpesvirus 8] [EntityWithAccessionedSequence:9980419] S-GlcNAc-N18,N22,N31,N202-ORF74 [Golgi membrane] [Human herpesvirus 8] [EntityWithAccessionedSequence:9980474] S-GlcNAc-N18,N22,N31,N202-ORF74 [clathrin-coated endocytic vesicle membrane] [Human herpesvirus 8] |
| (referenceSequence) | [ModifiedResidue:9980401] N4-glycosyl-L-asparagine at 22 [ModifiedResidue:9980402] N4-glycosyl-L-asparagine at 202 [ModifiedResidue:9980405] N4-glycosyl-L-asparagine at 31 [ModifiedResidue:9980407] N4-glycosyl-L-asparagine at 18 [ModifiedResidue:9980416] O4'-sulfo-L-tyrosine at unknown position |
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No pathways have been reviewed or authored by UniProt:Q98146 ORF74 (9973379)
