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Details on Person UniProt:F5HDB7 gL
| Class:Id | ReferenceGeneProduct:9973375 |
|---|---|
| _chainChangeLog | signal peptide:1-20 for 9973375 added on Fri Feb 20 2026;chain:21-167 for 9973375 added on Fri Feb 20 2026 |
| _displayName | UniProt:F5HDB7 gL |
| _timestamp | 2026-02-20 22:54:56 |
| chain | signal peptide:1-20 chain:21-167 |
| checksum | F711D54C707A8106 |
| comment | FUNCTION The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH. Targets heparan sulfate proteoglycans of the syndecan family as well as host EPHA2 to promote viral entry.SUBUNIT Interacts with glycoprotein H (gH); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion. When in complex with gH, interacts with host EPHA2; this interaction triggers EPHA2 phosphorylation and endocytosis, allowing virus entry.SUBCELLULAR LOCATION gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs.SIMILARITY Belongs to the herpesviridae glycoprotein L family. |
| created | [InstanceEdit:9973335] Orlic-Milacic, Marija, 2025-11-14 |
| description | recommendedName: fullName evidence="1"Envelope glycoprotein L shortName evidence="1"gL |
| geneName | gL 47 |
| identifier | F5HDB7 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Fusion of virus membrane with host cell membrane Fusion of virus membrane with host membrane Glycoprotein Host cell membrane Host Golgi apparatus Host membrane Membrane Reference proteome Signal Viral envelope protein Viral penetration into host cytoplasm Virion Virus entry into host cell |
| modified | [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | gL |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | GL_HHV8P |
| sequenceLength | 167 |
| species | [Species:2671781] Human herpesvirus 8 |
| (referenceEntity) | [EntityWithAccessionedSequence:9973171] gL [endoplasmic reticulum membrane] [Human herpesvirus 8] [EntityWithAccessionedSequence:9973235] gL [plasma membrane] [Human herpesvirus 8] [EntityWithAccessionedSequence:9973336] GlcNAc-N118,N141-gL [trans-Golgi network membrane] [Human herpesvirus 8] [EntityWithAccessionedSequence:9973357] gL [virion membrane] [Human herpesvirus 8] [EntityWithAccessionedSequence:9980690] GlcNAc-N118,N141-gL [plasma membrane] [Human herpesvirus 8] [EntityWithAccessionedSequence:9987206] GlcNAc-N118,N141-gL [viral envelope] [Human herpesvirus 8] |
| (referenceSequence) | [ModifiedResidue:9979379] N4-glycosyl-L-asparagine at 118 [ModifiedResidue:9979384] N4-glycosyl-L-asparagine at 141 |
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No pathways have been reviewed or authored by UniProt:F5HDB7 gL (9973375)
