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Details on Person UniProt:F5HFA1 ORF46
| Class:Id | ReferenceGeneProduct:9973367 |
|---|---|
| _chainChangeLog | chain:1-255 for 9973367 added on Fri Feb 20 2026 |
| _displayName | UniProt:F5HFA1 ORF46 |
| _timestamp | 2026-02-20 22:05:31 |
| chain | chain:1-255 |
| checksum | 3DF95D552D0C97C5 |
| comment | FUNCTION Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly in terminally differentiated cells which lack DNA repair enzymes.CATALYTIC ACTIVITY Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.SUBCELLULAR LOCATION Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. |
| created | [InstanceEdit:9973335] Orlic-Milacic, Marija, 2025-11-14 |
| description | recommendedName: fullName evidence="1"Uracil-DNA glycosylase shortName evidence="1"UDG ecNumber evidence="1"3.2.2.27 alternativeName: fullName evidence="1"UNG |
| geneName | ORF46 |
| identifier | F5HFA1 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure DNA damage DNA repair Host nucleus Hydrolase Reference proteome |
| modified | [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | ORF46 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | UNG_HHV8P |
| sequenceLength | 255 |
| species | [Species:2671781] Human herpesvirus 8 |
| (referenceEntity) | [EntityWithAccessionedSequence:9973206] ORF46 [nucleoplasm] [Human herpesvirus 8] [EntityWithAccessionedSequence:9979372] ORF46 [cytosol] [Human herpesvirus 8] |
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No pathways have been reviewed or authored by UniProt:F5HFA1 ORF46 (9973367)
