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Details on Person UniProt:Q2HRB2 ORF20
| Class:Id | ReferenceGeneProduct:9973364 |
|---|---|
| _chainChangeLog | chain:1-257 for 9973364 added on Fri Feb 20 2026 |
| _displayName | UniProt:Q2HRB2 ORF20 |
| _timestamp | 2026-02-20 21:35:53 |
| chain | chain:1-257 |
| checksum | D2D4C4941598408F |
| comment | FUNCTION May participate in nuclear egress of viral particles. Plays a role in the dispersal of several host nucleolar proteins including NCL/nucleolin and NPM1. Since deletion of host NCL/nucleolin negatively impact on nuclear egress, UL24 supposedly acts on this process through its effect on host nucleoli (By similarity). Induces cell cycle arrest in host cells at the G2/M phase following by apoptosis. The mechanism involves the inhibition of host mitotic complex cyclin-B/CDK1.SUBCELLULAR LOCATION Expressed late in the infection cycle.SIMILARITY Belongs to the herpesviridae UL24 family. |
| created | [InstanceEdit:9973335] Orlic-Milacic, Marija, 2025-11-14 |
| description | recommendedName: Protein UL24 homolog |
| geneName | ORF20 |
| identifier | Q2HRB2 |
| isSequenceChanged | FALSE |
| keyword | Host cytoplasm Host G2/M cell cycle arrest by virus Host Golgi apparatus Host nucleus Host-virus interaction Modulation of host cell cycle by virus Reference proteome Virion |
| modified | [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | ORF20 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | UL24_HHV8P |
| sequenceLength | 257 |
| species | [Species:2671781] Human herpesvirus 8 |
| (referenceEntity) | [EntityWithAccessionedSequence:9973198] ORF20 [Golgi lumen] [Human herpesvirus 8] [EntityWithAccessionedSequence:9973269] ORF20 [cytosol] [Human herpesvirus 8] [EntityWithAccessionedSequence:9973274] ORF20 [viral capsid] [Human herpesvirus 8] [EntityWithAccessionedSequence:9973295] ORF20 [nucleoplasm] [Human herpesvirus 8] |
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No pathways have been reviewed or authored by UniProt:Q2HRB2 ORF20 (9973364)
