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Details on Person UniProt:F5HB81 gB
Class:Id
ReferenceGeneProduct:9973332
_chainChangeLog
signal peptide:1-26 for 9973332 added on Fri Feb 20 2026;chain:27-845 for 9973332 added on Fri Feb 20 2026
_displayName
UniProt:F5HB81 gB
_timestamp
2026-02-20 21:59:27
chain
signal peptide:1-26 chain:27-845
checksum
C44A5F2FF29B1E41
comment
FUNCTION Envelope glycoprotein that forms spikes at the surface of the virion envelope. Participates in viral entry through an RGD motif that binds ITGAV-ITGB3. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.SUBUNIT Homotrimer; disulfide-linked. Binds to heparan sulfate proteoglycans. Interacts with gH/gL heterodimer (By similarity). Interacts with host ITGAV-ITGB3; this interaction mediates viral entry.INTERACTION During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).PTM A proteolytic cleavage by host furin generates two subunits that remain linked by disulfide bonds.SIMILARITY Belongs to the herpesviridae glycoprotein B family.
