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Details on Person UniProt:F5HIC6 vIRF-3
| Class:Id | ReferenceGeneProduct:9973303 |
|---|---|
| _chainChangeLog | chain:1-566 for 9973303 added on Fri Feb 20 2026 |
| _displayName | UniProt:F5HIC6 vIRF-3 |
| _timestamp | 2026-02-20 23:01:46 |
| chain | chain:1-566 |
| checksum | 822C557407A8C84B |
| comment | FUNCTION Plays a role in the inhibition of host immune response. Interferes with the transactivating potential of cellular IRFs IRF3 and IRF7 that play a critical role in the induction of IFNA and IFNB genes. Additionally, interferes with surface major histocompatibility complex class II (MHC-II) antigen presentation.SUBUNIT Interacts with host SKP2 (PubMed:22453922). Interacts with host USP7 (PubMed:29343584).SIMILARITY Belongs to the IRF family. |
| created | [InstanceEdit:9973335] Orlic-Milacic, Marija, 2025-11-14 |
| description | recommendedName: Viral IRF3-like protein shortName: VIRF-3 |
| geneName | vIRF-3 |
| identifier | F5HIC6 |
| isSequenceChanged | FALSE |
| keyword | DNA-binding Host-virus interaction Inhibition of host adaptive immune response by virus Inhibition of host MHC class II molecule presentation by virus Reference proteome Transcription Transcription regulation Viral immunoevasion |
| modified | [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | vIRF-3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | VIRF3_HHV8P |
| sequenceLength | 566 |
| species | [Species:2671781] Human herpesvirus 8 |
| (referenceEntity) | [EntityWithAccessionedSequence:9973230] vIRF-3 [nucleoplasm] [Human herpesvirus 8] [EntityWithAccessionedSequence:9980162] vIRF-3 [cytosol] [Human herpesvirus 8] [EntityWithAccessionedSequence:9980278] polySUMO2-vIRF-3 [nucleoplasm] [Human herpesvirus 8] [EntityWithAccessionedSequence:9980283] p-T564-polySUMO2-vIRF-3 [nucleoplasm] [Human herpesvirus 8] [EntityWithAccessionedSequence:9980289] polySUMO2-vIRF-3 [cytosol] [Human herpesvirus 8] |
| (referenceSequence) | [GroupModifiedResidue:9980277] sumoylated lysine (polySUMO2 [nucleoplasm]) at unknown position [ModifiedResidue:9980285] O-phospho-L-threonine at 564 |
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No pathways have been reviewed or authored by UniProt:F5HIC6 vIRF-3 (9973303)
