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Details on Person UniProt:F5HGH5 vPK
| Class:Id | ReferenceGeneProduct:9973290 |
|---|---|
| _chainChangeLog | chain:1-444 for 9973290 added on Fri Feb 20 2026 |
| _displayName | UniProt:F5HGH5 vPK |
| _timestamp | 2026-02-20 23:13:03 |
| chain | chain:1-444 |
| checksum | 589B2617E3900D80 |
| comment | FUNCTION Serine/threonine protein kinase that plays a role in viral gene expression, viral DNA replication and encapsidation, and nuclear egress of virions. Regulates host transcriptional activity through interactions with RNA helicase and c-Jun N-terminal kinase (JNK) and viral transcriptional activity through interactions with the viral protein K-bZIP/K8 (PubMed:17108053). Induces host chromosome condensation and phosphorylation of histone H3. Phosphorylates the DNA polymerase processivity factor hence modulating its processivity function. Inhibits the host Wnt signaling pathway via direct interactions with beta-catenin/CTNNB1 while the kinase activity of vPK is not required for this inhibitory activity. Also phosphorylates host SAMHD1 and thereby counteracts its antiviral effect by reducing its dNTP hydrolase activity.CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)SUBUNIT Interacts with protein K-bZIP/K8 (PubMed:17108053). Interacts with host beta-catenin/CTNNB1 (PubMed:29432739).SUBCELLULAR LOCATION AUtophosphorylated. |
| created | [InstanceEdit:9973335] Orlic-Milacic, Marija, 2025-11-14 |
| description | recommendedName: Viral protein kinase ecNumber evidence="9"2.7.11.1 |
| geneName | vPK ORF36 |
| identifier | F5HGH5 |
| isSequenceChanged | FALSE |
| keyword | ATP-binding Host nucleus Kinase Nucleotide-binding Reference proteome Transferase |
| modified | [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | vPK |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | VPK_HHV8P |
| sequenceLength | 444 |
| species | [Species:2671781] Human herpesvirus 8 |
| (referenceEntity) | [EntityWithAccessionedSequence:9973302] p-S-vPK [nucleoplasm] [Human herpesvirus 8] [EntityWithAccessionedSequence:9975998] vPK [cytosol] [Human herpesvirus 8] [EntityWithAccessionedSequence:9976013] p-S-vPK [cytosol] [Human herpesvirus 8] [EntityWithAccessionedSequence:9987109] p-S-vPK [viral tegument] [Human herpesvirus 8] |
| (referenceSequence) | [ModifiedResidue:9976015] O-phospho-L-serine at unknown position |
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No pathways have been reviewed or authored by UniProt:F5HGH5 vPK (9973290)
