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Details on Person UniProt:F5HF47 ORF68
| Class:Id | ReferenceGeneProduct:9973283 |
|---|---|
| _chainChangeLog | chain:1-467 for 9973283 added on Fri Feb 20 2026 |
| _displayName | UniProt:F5HF47 ORF68 |
| _timestamp | 2026-02-20 22:17:40 |
| chain | chain:1-467 |
| checksum | 3B3C423978D2A52C |
| comment | FUNCTION Plays a role in efficient localization of neo-synthesized capsids to nuclear replication compartments, thereby controlling cleavage and packaging of virus genomic DNA (PubMed:29875246). Facilitates thereby the transfer of newly replicated viral genomes to the packaging motor (PubMed:33554858).SUBUNIT Forms a homopentameric ring.SUBCELLULAR LOCATION Localizes to viral replication compartments.DISRUPTION PHENOTYPE Deletion mutants maintain viral DNA replication and late gene expression but does not produce infectious virions. In addition, viral DNA is not cleaved after replication.SIMILARITY Belongs to the herpesviridae UL32 protein family. |
| created | [InstanceEdit:9973335] Orlic-Milacic, Marija, 2025-11-14 |
| description | recommendedName: Packaging protein UL32 homolog |
| geneName | ORF68 |
| identifier | F5HF47 |
| isSequenceChanged | FALSE |
| keyword | Host cytoplasm Host nucleus Metal-binding Reference proteome Zinc Zinc-finger |
| modified | [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | ORF68 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | UL32_HHV8P |
| sequenceLength | 467 |
| species | [Species:2671781] Human herpesvirus 8 |
| (referenceEntity) | [EntityWithAccessionedSequence:9973238] ORF68 [nucleoplasm] [Human herpesvirus 8] [EntityWithAccessionedSequence:9973309] ORF68 [cytosol] [Human herpesvirus 8] |
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No pathways have been reviewed or authored by UniProt:F5HF47 ORF68 (9973283)
