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Details on Person UniProt:Q9QR69 K15
| Class:Id | ReferenceGeneProduct:9973272 |
|---|---|
| _chainChangeLog | signal peptide:1-26 for 9973272 added on Fri Feb 20 2026;chain:27-489 for 9973272 added on Fri Feb 20 2026 |
| _displayName | UniProt:Q9QR69 K15 |
| _timestamp | 2026-02-20 21:31:11 |
| chain | signal peptide:1-26 chain:27-489 |
| checksum | 0FDB473474121743 |
| comment | FUNCTION Plays a crucial role for reactivation of the virus from latency, early viral gene expression and virus production. Modulates host signaling pathways including activation of MAP kinases c-JUN-N-terminal kinase (JNK), ERK2, and NF-kappa-B resulting in the activation of AP-1 and NFAT-dependent gene expression in B-lymphocytes. When expressed in epithelial cells, induces the expression of several inflammatory and angiogenic genes. Also interferes with B-lymphocytes signaling through interaction with host LYN kinase.SUBUNIT Interacts with host LYN; this interaction modulates B-cells signaling. Interacts with host ITSN2.SUBCELLULAR LOCATION Localizes to the trans-Golgi network (TGN) compartment during latency and relocalizes to the cell periphery when the lytic program is induced. |
| created | [InstanceEdit:9973335] Orlic-Milacic, Marija, 2025-11-14 |
| description | recommendedName: Protein K15 |
| geneName | K15 |
| identifier | Q9QR69 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Host cell membrane Host Golgi apparatus Host membrane Host-virus interaction Membrane Reference proteome Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | K15 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | K15_HHV8P |
| sequenceLength | 489 |
| species | [Species:2671781] Human herpesvirus 8 |
| (referenceEntity) | [EntityWithAccessionedSequence:9973185] K15 [plasma membrane] [Human herpesvirus 8] [EntityWithAccessionedSequence:9973242] K15 [Golgi membrane] [Human herpesvirus 8] [EntityWithAccessionedSequence:9973265] K15 [endoplasmic reticulum membrane] [Human herpesvirus 8] [EntityWithAccessionedSequence:9982517] p-Y481-K15 [plasma membrane] [Human herpesvirus 8] [EntityWithAccessionedSequence:9982528] p-Y481-K15 [endosome membrane] [Human herpesvirus 8] |
| (referenceSequence) | [ModifiedResidue:9982520] O4'-phospho-L-tyrosine at 481 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9QR69 K15 (9973272)
