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Details on Person UniProt:P90495 K3
| Class:Id | ReferenceGeneProduct:9973262 |
|---|---|
| _chainChangeLog | chain:1-333 for 9973262 added on Fri Feb 20 2026 |
| _displayName | UniProt:P90495 K3 |
| _timestamp | 2026-02-20 21:41:29 |
| chain | chain:1-333 |
| checksum | C9CCE79B87D3F553 |
| comment | FUNCTION Membrane-bound E3 ubiquitin ligase expressed during late stages of lytic replication to mediate polyubiquitination of various host membrane proteins related to the immune response (PubMed:24899205). Promotes ubiquitination and subsequent degradation of host MHC-I and CD1D molecules, DC-SIGN and DC-SIGNR, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes (PubMed:10859362, PubMed:11756476). Binds target molecules through transmembrane interaction. E3 ubiquitin-protein ligases accept ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfer it to target protein. The result of this ubiquitination is the enhancement of the endocytosis of the target chain and the delivery to the lysosome, where it is proteolytically destroyed. Induces ubiquitination not only on lysines, but also on cysteine residues.CATALYTIC ACTIVITY [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Binds human MHC-I and CD1D.INTERACTION Probably exerts its effects at the plasma membrane during viral infection.MISCELLANEOUS Specific for HLA-A, HLA-B, HLA-C and HLA-E alleles. |
| created | [InstanceEdit:9973335] Orlic-Milacic, Marija, 2025-11-14 |
| description | recommendedName: E3 ubiquitin-protein ligase MIR1 ecNumber evidence="9"2.3.2.36 alternativeName: IE1B protein alternativeName: Modulator of immune recognition 1 alternativeName: ORF K3 alternativeName: fullName evidence="11"RING-type E3 ubiquitin transferase MIR1 |
| geneName | K3 |
| identifier | P90495 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Early protein Host cell membrane Host endoplasmic reticulum Host membrane Host-virus interaction Inhibition of host innate immune response by virus Inhibition of host interferon receptors by virus Inhibition of host interferon signaling pathway by virus Interferon antiviral system evasion Membrane Metal-binding Reference proteome Transferase Transmembrane Transmembrane helix Ubl conjugation pathway Viral immunoevasion Zinc Zinc-finger |
| modified | [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | K3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | MIR1_HHV8P O40920 Q2HRC5 |
| sequenceLength | 333 |
| species | [Species:2671781] Human herpesvirus 8 |
| (referenceEntity) | [EntityWithAccessionedSequence:9973263] K3 [endoplasmic reticulum membrane] [Human herpesvirus 8] [EntityWithAccessionedSequence:9973370] K3 [plasma membrane] [Human herpesvirus 8] [EntityWithAccessionedSequence:9978796] OGlcNAc-K3 [endoplasmic reticulum membrane] [Human herpesvirus 8] [EntityWithAccessionedSequence:9978848] OGlcNAc-K3 [plasma membrane] [Human herpesvirus 8] |
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No pathways have been reviewed or authored by UniProt:P90495 K3 (9973262)
