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Details on Person UniProt:F5HAK9 gH
| Class:Id | ReferenceGeneProduct:9973256 |
|---|---|
| _chainChangeLog | signal peptide:1-21 for 9973256 added on Fri Feb 20 2026;chain:22-730 for 9973256 added on Fri Feb 20 2026 |
| _displayName | UniProt:F5HAK9 gH |
| _timestamp | 2026-02-20 21:39:50 |
| chain | signal peptide:1-21 chain:22-730 |
| checksum | B5DB4B733DDFE451 |
| comment | FUNCTION The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis (By similarity). Targets host EPHA2 to promote KSHV entry.SUBUNIT Interacts with glycoprotein L (gL); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion (By similarity). When in complex with gL, interacts with host EPHA2; this interaction triggers EPHA2 phosphorylation and endocytosis allowing KSHV entry.SUBCELLULAR LOCATION During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).PTM N-glycosylated, O-glycosylated, and sialylated.SIMILARITY Belongs to the herpesviridae glycoprotein H family. |
| created | [InstanceEdit:9973335] Orlic-Milacic, Marija, 2025-11-14 |
| description | recommendedName: fullName evidence="1"Envelope glycoprotein H shortName evidence="1"gH |
| geneName | gH ORF22 |
| identifier | F5HAK9 |
| isSequenceChanged | FALSE |
| keyword | Fusion of virus membrane with host cell membrane Fusion of virus membrane with host membrane Glycoprotein Host cell membrane Host endosome Host membrane Membrane Reference proteome Sialic acid Signal Transmembrane Transmembrane helix Viral envelope protein Viral penetration into host cytoplasm Virion Virus entry into host cell |
| modified | [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | gH |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | GH_HHV8P |
| sequenceLength | 730 |
| species | [Species:2671781] Human herpesvirus 8 |
| (referenceEntity) | [EntityWithAccessionedSequence:9973163] GlcNAc-gH [plasma membrane] [Human herpesvirus 8] [EntityWithAccessionedSequence:9973229] gH [virion membrane] [Human herpesvirus 8] [EntityWithAccessionedSequence:9973330] gH [endosome membrane] [Human herpesvirus 8] [EntityWithAccessionedSequence:9973339] gH [endoplasmic reticulum membrane] [Human herpesvirus 8] [EntityWithAccessionedSequence:9973397] GlcNAc-gH [trans-Golgi network membrane] [Human herpesvirus 8] [EntityWithAccessionedSequence:9987194] GlcNAc-gH [viral envelope] [Human herpesvirus 8] |
| (referenceSequence) | [GroupModifiedResidue:9980670] N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at unknown position |
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No pathways have been reviewed or authored by UniProt:F5HAK9 gH (9973256)
