Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q2HR95 ORF37
| Class:Id | ReferenceGeneProduct:9973246 |
|---|---|
| _chainChangeLog | chain:1-486 for 9973246 added on Fri Feb 20 2026 |
| _displayName | UniProt:Q2HR95 ORF37 |
| _timestamp | 2026-02-20 21:46:49 |
| chain | chain:1-486 |
| checksum | D7E0FA2FCB04AACF |
| comment | FUNCTION Plays a role in processing non linear or branched viral DNA intermediates in order to promote the production of mature packaged unit-length linear progeny viral DNA molecules. Exhibits endonuclease and exonuclease activities and accepts both double-stranded and single-stranded DNA as substrate. Exonuclease digestion of DNA is in the 5'-> 3' direction and the products are 5'-monophosphate nucleosides. Additionally, forms a recombinase with the major DNA-binding protein, which displays strand exchange activity. Also acts as a cytoplasmic RNA endonuclease that induces degradation of the majority of the cellular messenger RNAs during early lytic infection. The resulting inhibition of cellular protein synthesis serves to ensure maximal viral gene expression and evasion from host immune response. Internally cleaves host mRNAs which are then degraded by the cellular exonuclease XRN1. Bypasses therefore the regulatory steps of deadenylation and decapping normally required for XRN1 activation. In addition, inhibits host inflammasome activation to promote viral lytic replication by interacting with host AIM2 and disrupting its polymerization (PubMed:37364111).SUBUNIT Forms a complex with the DNA polymerase, the DNA polymerase processivity factor, and the major DNA binding protein.SUBCELLULAR LOCATION Belongs to the herpesviridae alkaline nuclease family. |
| created | [InstanceEdit:9973335] Orlic-Milacic, Marija, 2025-11-14 |
| description | recommendedName: fullName evidence="1"Shutoff alkaline exonuclease shortName evidence="1"SOX ecNumber evidence="1"3.1.-.- |
| geneName | ORF37 |
| identifier | Q2HR95 |
| isSequenceChanged | FALSE |
| keyword | Decay of host mRNAs by virus Early protein Endonuclease Eukaryotic host gene expression shutoff by virus Exonuclease Host cytoplasm Host gene expression shutoff by virus Host mRNA suppression by virus Host nucleus Host-virus interaction Hydrolase Nuclease Reference proteome RNA-binding |
| modified | [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | ORF37 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | AN_HHV8P |
| sequenceLength | 486 |
| species | [Species:2671781] Human herpesvirus 8 |
| (referenceEntity) | [EntityWithAccessionedSequence:9973374] ORF37 [cytosol] [Human herpesvirus 8] [EntityWithAccessionedSequence:9973395] ORF37 [nucleoplasm] [Human herpesvirus 8] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q2HR95 ORF37 (9973246)
