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Details on Person UniProt:Q2HRD0 ORF9
| Class:Id | ReferenceGeneProduct:9973239 |
|---|---|
| _chainChangeLog | chain:1-1012 for 9973239 added on Fri Feb 20 2026 |
| _displayName | UniProt:Q2HRD0 ORF9 |
| _timestamp | 2026-02-20 21:29:18 |
| chain | chain:1-1012 |
| checksum | 85630925BD54CC9C |
| comment | FUNCTION Replicates viral genomic DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein. Additionally, the polymerase contains an intrinsic ribonuclease H (RNase H) activity that specifically degrades RNA/DNA heteroduplexes or duplex DNA substrates in the 5' to 3' direction. Therefore, it can catalyze the excision of the RNA primers that initiate the synthesis of Okazaki fragments at a replication fork during viral DNA replication (By similarity).CATALYTIC ACTIVITY DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphateCATALYTIC ACTIVITY Endonucleolytic cleavage to 5'-phosphomonoester.SUBUNIT Forms a complex with the ssDNA-binding protein, the DNA polymerase processivity factor, and the alkaline exonuclease. Interacts with the putative helicase-primase complex subunit; this interaction may coordinate leading and lagging strand DNA synthesis at the replication fork (By similarity).SUBCELLULAR LOCATION The protein is present at discrete sites in nuclei, called replication compartments where viral DNA replication occurs.SIMILARITY Belongs to the DNA polymerase type-B family. |
| created | [InstanceEdit:9973335] Orlic-Milacic, Marija, 2025-11-14 |
| description | recommendedName: DNA polymerase catalytic subunit ecNumber: 2.7.7.7 ecNumber: 3.1.26.4 |
| geneName | ORF9 |
| identifier | Q2HRD0 |
| isSequenceChanged | FALSE |
| keyword | DNA replication DNA-binding DNA-directed DNA polymerase Endonuclease Host nucleus Hydrolase Multifunctional enzyme Nuclease Nucleotidyltransferase Reference proteome Transferase Viral DNA replication |
| modified | [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | ORF9 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | DPOL_HHV8P |
| sequenceLength | 1012 |
| species | [Species:2671781] Human herpesvirus 8 |
| (referenceEntity) | [EntityWithAccessionedSequence:9973366] ORF9 [nucleoplasm] [Human herpesvirus 8] [EntityWithAccessionedSequence:9979739] ORF9 [cytosol] [Human herpesvirus 8] |
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No pathways have been reviewed or authored by UniProt:Q2HRD0 ORF9 (9973239)
